@@ -5,21 +5,24 @@ Introduction
5
5
============
6
6
<p align-text =" justify " > RNA editing is a post-transcriptional phenomenon
7
7
involving the insertion/deletion or substitution of specific bases in precise RNA localizations.
8
- In human , RNA editing occurs by deamination of cytosine to uridine (C-to-U) or mostly by the
8
+ In humans , RNA editing occurs by deamination of cytosine to uridine (C-to-U) or mostly by the
9
9
adenosine to inosine (A-to-I) conversion through ADAR enzymes. A-to-I substitutions may have
10
10
profound functional consequences and have been linked to a variety of human diseases including
11
- neurological and neurodegenerative disorders or cancer. Next generation sequencing technologies
12
- offer the unique opportunity to investigate in depth RNA editing even though no dedicated
11
+ neurological and neurodegenerative disorders or cancer. Next- generation sequencing technologies
12
+ offer the unique opportunity to investigate in- depth RNA editing even though no dedicated
13
13
software has been released up to now.
14
14
15
- REDItools are simple python scripts conceived to facilitate the investigation of RNA editing
16
- at large- scale and devoted to research groups that would to explore such phenomenon in own
15
+ REDItools are simple Python scripts conceived to facilitate the investigation of RNA editing
16
+ at large scale and devoted to research groups that would explore such phenomena in own
17
17
data but don’t have sufficient bioinformatics skills.
18
18
They work on main operating systems (although unix/linux-based OS are preferred), can handle reads from whatever
19
- platform in the standard BAM format and implement a variety of filters.</p >
19
+ platform in the standard BAM format, and implement various filters.</p >
20
20
21
21
<a href =" https://github.com/BioinfoUNIBA/REDItools/blob/master/README_1.md " >REDItools V1 manual</a >
22
22
<br ><br >
23
23
<a href =" https://github.com/BioinfoUNIBA/REDItools2 " >REDItools V2 manual</a >
24
- <p ><b >Note. </b >REDItools V2 is the latest optimized, parallel multi-node version of REDItools.</p >
24
+ <br ><br >
25
+ <a href =" https://github.com/BioinfoUNIBA/REDItools3 " >REDItools V3 manual</a >
26
+ <p ><b >Note. </b >REDItools V2 is useful for HPC environments.</p >
27
+ </b >REDItools V3 is the latest optimized version for large-scale investigations.</p >
25
28
<p ><b >Important. </b >Reditool_DNA_RNA.py v1.3 available at <a href =" /NPscripts/REDItoolDnaRnav13.py " download =" REDItoolDnaRnav13.py " >this link </a ></p >
0 commit comments