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README.md

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<p align-text="justify"> RNA editing is a post-transcriptional phenomenon
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involving the insertion/deletion or substitution of specific bases in precise RNA localizations.
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In human, RNA editing occurs by deamination of cytosine to uridine (C-to-U) or mostly by the
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In humans, RNA editing occurs by deamination of cytosine to uridine (C-to-U) or mostly by the
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adenosine to inosine (A-to-I) conversion through ADAR enzymes. A-to-I substitutions may have
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profound functional consequences and have been linked to a variety of human diseases including
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neurological and neurodegenerative disorders or cancer. Next generation sequencing technologies
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offer the unique opportunity to investigate in depth RNA editing even though no dedicated
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neurological and neurodegenerative disorders or cancer. Next-generation sequencing technologies
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offer the unique opportunity to investigate in-depth RNA editing even though no dedicated
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software has been released up to now.
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REDItools are simple python scripts conceived to facilitate the investigation of RNA editing
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at large-scale and devoted to research groups that would to explore such phenomenon in own
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REDItools are simple Python scripts conceived to facilitate the investigation of RNA editing
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at large scale and devoted to research groups that would explore such phenomena in own
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data but don’t have sufficient bioinformatics skills.
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They work on main operating systems (although unix/linux-based OS are preferred), can handle reads from whatever
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platform in the standard BAM format and implement a variety of filters.</p>
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platform in the standard BAM format, and implement various filters.</p>
2020

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<a href="https://github.com/BioinfoUNIBA/REDItools/blob/master/README_1.md">REDItools V1 manual</a>
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<br><br>
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<a href="https://github.com/BioinfoUNIBA/REDItools2">REDItools V2 manual</a>
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<p><b>Note. </b>REDItools V2 is the latest optimized, parallel multi-node version of REDItools.</p>
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<br><br>
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<a href="https://github.com/BioinfoUNIBA/REDItools3">REDItools V3 manual</a>
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<p><b>Note. </b>REDItools V2 is useful for HPC environments.</p>
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</b>REDItools V3 is the latest optimized version for large-scale investigations.</p>
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<p><b>Important. </b>Reditool_DNA_RNA.py v1.3 available at <a href="/NPscripts/REDItoolDnaRnav13.py" download="REDItoolDnaRnav13.py">this link </a></p>

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