diff --git a/cpython-unix/build-cpython.sh b/cpython-unix/build-cpython.sh
index 820b6a2d..75f330d9 100755
--- a/cpython-unix/build-cpython.sh
+++ b/cpython-unix/build-cpython.sh
@@ -653,7 +653,8 @@ fi
 # We patched configure.ac above. Reflect those changes.
 autoconf
 
-CFLAGS=$CFLAGS CPPFLAGS=$CFLAGS LDFLAGS=$LDFLAGS \
+# Ensure `CFLAGS` are propagated to JIT compilation for 3.13+
+CFLAGS=$CFLAGS CPPFLAGS=$CFLAGS JIT_CFLAGS=$CFLAGS LDFLAGS=$LDFLAGS \
     ./configure ${CONFIGURE_FLAGS}
 
 # Supplement produced Makefile with our modifications.
diff --git a/cpython-unix/patch-jit-cflags-314.patch b/cpython-unix/patch-jit-cflags-314.patch
index 3a16fb5d..a75563b4 100644
--- a/cpython-unix/patch-jit-cflags-314.patch
+++ b/cpython-unix/patch-jit-cflags-314.patch
@@ -1,5 +1,12 @@
+diff --git a/Misc/NEWS.d/next/Build/2025-05-19-18-09-20.gh-issue-134273.ZAliyy.rst b/Misc/NEWS.d/next/Build/2025-05-19-18-09-20.gh-issue-134273.ZAliyy.rst
+new file mode 100644
+index 00000000000..3eb13cefbe6
+--- /dev/null
++++ b/Misc/NEWS.d/next/Build/2025-05-19-18-09-20.gh-issue-134273.ZAliyy.rst
+@@ -0,0 +1 @@
++Add support for configuring compiler flags for the JIT with ``CFLAGS_JIT``
 diff --git a/Tools/jit/_targets.py b/Tools/jit/_targets.py
-index d0a1c081ffe..deb83f275d2 100644
+index d0a1c081ffe..b383e39da19 100644
 --- a/Tools/jit/_targets.py
 +++ b/Tools/jit/_targets.py
 @@ -10,6 +10,7 @@
@@ -18,16 +25,25 @@ index d0a1c081ffe..deb83f275d2 100644
      known_symbols: dict[str, int] = dataclasses.field(default_factory=dict)
      pyconfig_dir: pathlib.Path = pathlib.Path.cwd().resolve()
  
-@@ -120,6 +122,7 @@ async def _compile(
-     ) -> _stencils.StencilGroup:
-         o = tempdir / f"{opname}.o"
-         args = [
+@@ -62,6 +64,7 @@ def _compute_digest(self) -> str:
+         hasher = hashlib.sha256()
+         hasher.update(self.triple.encode())
+         hasher.update(self.debug.to_bytes())
++        hasher.update(self.cflags.encode())
+         # These dependencies are also reflected in _JITSources in regen.targets:
+         hasher.update(PYTHON_EXECUTOR_CASES_C_H.read_bytes())
+         hasher.update((self.pyconfig_dir / "pyconfig.h").read_bytes())
+@@ -155,6 +158,8 @@ async def _compile(
+             f"{o}",
+             f"{c}",
+             *self.args,
++            # Allow user-provided CFLAGS to override any defaults
 +            *shlex.split(self.cflags),
-             f"--target={self.triple}",
-             "-DPy_BUILD_CORE_MODULE",
-             "-D_DEBUG" if self.debug else "-DNDEBUG",
+         ]
+         await _llvm.run("clang", args, echo=self.verbose)
+         return await self._parse(o)
 diff --git a/Tools/jit/build.py b/Tools/jit/build.py
-index 1afd0c76bad..96c4cb07593 100644
+index 1afd0c76bad..a0733005929 100644
 --- a/Tools/jit/build.py
 +++ b/Tools/jit/build.py
 @@ -39,11 +39,15 @@
@@ -35,19 +51,19 @@ index 1afd0c76bad..96c4cb07593 100644
          "-v", "--verbose", action="store_true", help="echo commands as they are run"
      )
 +    parser.add_argument(
-+        "--with-cflags", help="additional flags to pass to the compiler", default=""
++        "--cflags", help="additional flags to pass to the compiler", default=""
 +    )
      args = parser.parse_args()
      for target in args.target:
          target.debug = args.debug
          target.force = args.force
          target.verbose = args.verbose
-+        target.cflags = args.with_cflags
++        target.cflags = args.cflags
          target.pyconfig_dir = args.pyconfig_dir
          target.build(
              comment=comment,
 diff --git a/configure b/configure
-index 884f8a4b068..2e6740c33d9 100755
+index 029bf527da4..fef9f2d7da9 100755
 --- a/configure
 +++ b/configure
 @@ -10863,7 +10863,7 @@ then :
@@ -55,12 +71,12 @@ index 884f8a4b068..2e6740c33d9 100755
  else case e in #(
    e) as_fn_append CFLAGS_NODIST " $jit_flags"
 -           REGEN_JIT_COMMAND="\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir ."
-+           REGEN_JIT_COMMAND="\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir .  --with-cflags=\"\$(CONFIGURE_CFLAGS)\""
++           REGEN_JIT_COMMAND="\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir . --cflags=\"$CFLAGS_JIT\""
             JIT_STENCILS_H="jit_stencils.h"
             if test "x$Py_DEBUG" = xtrue
  then :
 diff --git a/configure.ac b/configure.ac
-index cf25148bad2..f8bfab7bf96 100644
+index 371b2e8ed73..cc37a636c52 100644
 --- a/configure.ac
 +++ b/configure.ac
 @@ -2776,7 +2776,7 @@ AS_VAR_IF([jit_flags],
@@ -68,7 +84,7 @@ index cf25148bad2..f8bfab7bf96 100644
            [AS_VAR_APPEND([CFLAGS_NODIST], [" $jit_flags"])
             AS_VAR_SET([REGEN_JIT_COMMAND],
 -                      ["\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir ."])
-+                      ["\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir . --with-cflags=\"\$(CONFIGURE_CFLAGS)\""])
++                      ["\$(PYTHON_FOR_REGEN) \$(srcdir)/Tools/jit/build.py ${ARCH_TRIPLES:-$host} --output-dir . --pyconfig-dir . --cflags=\"$CFLAGS_JIT\""])
             AS_VAR_SET([JIT_STENCILS_H], ["jit_stencils.h"])
             AS_VAR_IF([Py_DEBUG],
                       [true],