diff --git a/crates/c-api/include/wasmtime/config.h b/crates/c-api/include/wasmtime/config.h
index 356764e42a43..0150ee01a59a 100644
--- a/crates/c-api/include/wasmtime/config.h
+++ b/crates/c-api/include/wasmtime/config.h
@@ -192,6 +192,14 @@ WASMTIME_CONFIG_PROP(void, wasm_multi_memory, bool)
  */
 WASMTIME_CONFIG_PROP(void, wasm_module_linking, bool)
 
+/**
+ * \brief Configures whether the WebAssembly memory64 proposal is
+ * enabled.
+ *
+ * This setting is `false` by default.
+ */
+WASMTIME_CONFIG_PROP(void, wasm_memory64, bool)
+
 /**
  * \brief Configures how JIT code will be compiled.
  *
diff --git a/crates/c-api/src/config.rs b/crates/c-api/src/config.rs
index 40def6148ff2..6386ca6c9116 100644
--- a/crates/c-api/src/config.rs
+++ b/crates/c-api/src/config.rs
@@ -100,6 +100,11 @@ pub extern "C" fn wasmtime_config_wasm_module_linking_set(c: &mut wasm_config_t,
     c.config.wasm_module_linking(enable);
 }
 
+#[no_mangle]
+pub extern "C" fn wasmtime_config_wasm_memory64_set(c: &mut wasm_config_t, enable: bool) {
+    c.config.wasm_memory64(enable);
+}
+
 #[no_mangle]
 pub extern "C" fn wasmtime_config_strategy_set(
     c: &mut wasm_config_t,
diff --git a/docs/stability-wasm-proposals-support.md b/docs/stability-wasm-proposals-support.md
index 3080869774ac..13dbf978ae96 100644
--- a/docs/stability-wasm-proposals-support.md
+++ b/docs/stability-wasm-proposals-support.md
@@ -23,6 +23,7 @@ vetted](./contributing-implementing-wasm-proposals.html).
 | **[Threads and Atomics]**                   | **In progress.**                 | `--enable-threads`     | [`wasm_threads`](https://docs.rs/wasmtime/*/wasmtime/struct.Config.html#method.wasm_threads) |
 | **[Multi-Memory]**                          | **Yes.**                         | `--enable-multi-memory`| [`wasm_multi_memory`](https://docs.rs/wasmtime/*/wasmtime/struct.Config.html#method.wasm_multi_memory) |
 | **[Module Linking]**                        | **Yes.**                         | `--enable-module-linking` | [`wasm_module_linking`](https://docs.rs/wasmtime/*/wasmtime/struct.Config.html#method.wasm_module_linking) |
+| **[Memory64]**                              | **Yes.**                         | `--enable-memory64`    | [`wasm_memory64`](https://docs.rs/wasmtime/*/wasmtime/struct.Config.html#method.wasm_memory64) |
 
 [config]: https://docs.rs/wasmtime/*/wasmtime/struct.Config.html
 [Multi-Value]: https://github.com/WebAssembly/spec/blob/master/proposals/multi-value/Overview.md
@@ -36,3 +37,4 @@ vetted](./contributing-implementing-wasm-proposals.html).
 [Threads and Atomics]: https://github.com/WebAssembly/threads/blob/master/proposals/threads/Overview.md
 [Multi-Memory]: https://github.com/WebAssembly/multi-memory/blob/master/proposals/multi-memory/Overview.md
 [Module Linking]: https://github.com/WebAssembly/module-linking/blob/master/proposals/module-linking/Explainer.md
+[Memory64]: https://github.com/WebAssembly/memory64/blob/master/proposals/memory64/Overview.md
diff --git a/src/lib.rs b/src/lib.rs
index facb0383c283..b8630d5a13bc 100644
--- a/src/lib.rs
+++ b/src/lib.rs
@@ -41,6 +41,7 @@ const SUPPORTED_WASM_FEATURES: &[(&str, &str)] = &[
     ("reference-types", "enables support for reference types"),
     ("simd", "enables support for proposed SIMD instructions"),
     ("threads", "enables support for WebAssembly threads"),
+    ("memory64", "enables support for 64-bit memories"),
 ];
 
 const SUPPORTED_WASI_MODULES: &[(&str, &str)] = &[
@@ -437,7 +438,7 @@ fn parse_wasm_features(features: &str) -> Result<wasmparser::WasmFeatures> {
         deterministic_only: false,
         multi_memory: all.unwrap_or(values["multi-memory"].unwrap_or(false)),
         exceptions: false,
-        memory64: false,
+        memory64: all.unwrap_or(values["memory64"].unwrap_or(false)),
     })
 }
 
@@ -561,7 +562,7 @@ mod test {
         assert!(!deterministic_only); // Not supported
         assert!(multi_memory);
         assert!(!exceptions); // Not supported
-        assert!(!memory64); // Not supported
+        assert!(memory64);
 
         Ok(())
     }
@@ -603,7 +604,7 @@ mod test {
     fn test_multiple_features() -> Result<()> {
         let options = CommonOptions::from_iter_safe(vec![
             "foo",
-            "--wasm-features=-reference-types,simd,multi-memory",
+            "--wasm-features=-reference-types,simd,multi-memory,memory64",
         ])?;
 
         let wasmparser::WasmFeatures {
@@ -630,7 +631,7 @@ mod test {
         assert!(!deterministic_only); // Not supported
         assert!(multi_memory);
         assert!(!exceptions); // Not supported
-        assert!(!memory64); // Not supported
+        assert!(memory64);
 
         Ok(())
     }
@@ -675,6 +676,7 @@ mod test {
     feature_test!(test_simd_feature, simd, "simd");
     feature_test!(test_threads_feature, threads, "threads");
     feature_test!(test_multi_memory_feature, multi_memory, "multi-memory");
+    feature_test!(test_memory64_feature, memory64, "memory64");
 
     #[test]
     fn test_default_modules() {