diff --git a/dwds/CHANGELOG.md b/dwds/CHANGELOG.md
index 747365d77..0b25f55e2 100644
--- a/dwds/CHANGELOG.md
+++ b/dwds/CHANGELOG.md
@@ -1,4 +1,5 @@
 ## 24.3.4-wip
+- Added support for some debugging APIs with the DDC library bundle format. - [#2566](https://github.com/dart-lang/webdev/issues/2566)
 
 ## 24.3.3
 
diff --git a/dwds/lib/src/debugging/dart_runtime_debugger.dart b/dwds/lib/src/debugging/dart_runtime_debugger.dart
index ed633ee48..bc0d79a9b 100644
--- a/dwds/lib/src/debugging/dart_runtime_debugger.dart
+++ b/dwds/lib/src/debugging/dart_runtime_debugger.dart
@@ -197,10 +197,38 @@ class DartRuntimeDebugger {
     );
   }
 
+  /// Generates a JS expression to invoke a Dart extension method.
   String invokeExtensionJsExpression(String methodName, String encodedJson) {
     return _generateJsExpression(
       "${_loadStrategy.loadModuleSnippet}('dart_sdk').developer.invokeExtension('$methodName', JSON.stringify($encodedJson));",
       "dartDevEmbedder.debugger.invokeExtension('$methodName', JSON.stringify($encodedJson));",
     );
   }
+
+  /// Generates a JS expression for calling a library method.
+  String callLibraryMethodJsExpression(
+    String libraryUri,
+    String methodName,
+  ) {
+    final findLibraryExpression = '''
+     (function() {
+       const sdk = ${_loadStrategy.loadModuleSnippet}('dart_sdk');
+       const dart = sdk.dart;
+       const library = dart.getLibrary('$libraryUri');
+       if (!library) throw 'cannot find library for $libraryUri';
+       return library;
+     })();
+     ''';
+
+    // `callLibraryMethod` expects an array of arguments. Chrome DevTools spreads
+    // arguments individually when calling functions. This code reconstructs the
+    // expected argument array.
+    return _generateJsExpression(
+      findLibraryExpression,
+      _wrapWithBundleLoader(
+        '',
+        'callLibraryMethod("$libraryUri", "$methodName", Array.from(arguments))',
+      ),
+    );
+  }
 }
diff --git a/dwds/lib/src/debugging/inspector.dart b/dwds/lib/src/debugging/inspector.dart
index 4f557d47f..f3ae1264c 100644
--- a/dwds/lib/src/debugging/inspector.dart
+++ b/dwds/lib/src/debugging/inspector.dart
@@ -14,6 +14,7 @@ import 'package:dwds/src/debugging/instance.dart';
 import 'package:dwds/src/debugging/libraries.dart';
 import 'package:dwds/src/debugging/location.dart';
 import 'package:dwds/src/debugging/remote_debugger.dart';
+import 'package:dwds/src/loaders/ddc_library_bundle.dart';
 import 'package:dwds/src/readers/asset_reader.dart';
 import 'package:dwds/src/utilities/conversions.dart';
 import 'package:dwds/src/utilities/dart_uri.dart';
@@ -301,11 +302,17 @@ class AppInspector implements AppInspectorInterface {
     String selector,
     List<RemoteObject> arguments,
   ) {
-    return _evaluateInLibrary(
-      library,
-      'function () { return this.$selector.apply(this, arguments);}',
-      arguments,
-    );
+    return globalToolConfiguration.loadStrategy is DdcLibraryBundleStrategy
+        ? _evaluateLibraryMethodWithDdcLibraryBundle(
+            library,
+            selector,
+            arguments,
+          )
+        : _evaluateInLibrary(
+            library,
+            'function () { return this.$selector.apply(this, arguments); }',
+            arguments,
+          );
   }
 
   /// Evaluate [expression] by calling Chrome's Runtime.evaluate.
@@ -340,19 +347,31 @@ class AppInspector implements AppInspectorInterface {
     if (libraryUri == null) {
       throwInvalidParam('invoke', 'library uri is null');
     }
-    final findLibrary = '''
-      (function() {
-        const sdk = ${globalToolConfiguration.loadStrategy.loadModuleSnippet}('dart_sdk');
-        const dart = sdk.dart;
-        const library = dart.getLibrary('$libraryUri');
-        if (!library) throw 'cannot find library for $libraryUri';
-        return library;
-      })();
-      ''';
-    final remoteLibrary = await jsEvaluate(findLibrary);
+    final findLibraryJsExpression = globalToolConfiguration
+        .loadStrategy.dartRuntimeDebugger
+        .callLibraryMethodJsExpression(libraryUri, jsFunction);
+
+    final remoteLibrary = await jsEvaluate(findLibraryJsExpression);
     return jsCallFunctionOn(remoteLibrary, jsFunction, arguments);
   }
 
+  /// Evaluates the specified top-level method [methodName] within [library]
+  /// using the Dart Development Compiler (DDC) library bundle strategy with
+  /// the given [arguments].
+  Future<RemoteObject> _evaluateLibraryMethodWithDdcLibraryBundle(
+    Library library,
+    String methodName,
+    List<RemoteObject> arguments,
+  ) {
+    final libraryUri = library.uri;
+    if (libraryUri == null) {
+      throwInvalidParam('invoke', 'library uri is null');
+    }
+    final expression = globalToolConfiguration.loadStrategy.dartRuntimeDebugger
+        .callLibraryMethodJsExpression(libraryUri, methodName);
+    return _jsCallFunction(expression, arguments);
+  }
+
   /// Call [function] with objects referred by [argumentIds] as arguments.
   @override
   Future<RemoteObject> callFunction(
diff --git a/dwds/test/common/chrome_proxy_service_common.dart b/dwds/test/common/chrome_proxy_service_common.dart
index f640ae0d1..650e0b883 100644
--- a/dwds/test/common/chrome_proxy_service_common.dart
+++ b/dwds/test/common/chrome_proxy_service_common.dart
@@ -1733,9 +1733,6 @@ void runTests({
                 .having((instance) => instance.kind, 'kind', 'String'),
           );
         },
-        skip: moduleFormat == ModuleFormat.ddc && canaryFeatures == true
-            ? 'https://github.com/dart-lang/webdev/issues/2566'
-            : null,
       );
 
       test(
@@ -1761,9 +1758,6 @@ void runTests({
                 .having((instance) => instance.kind, 'kind', 'Null'),
           );
         },
-        skip: moduleFormat == ModuleFormat.ddc && canaryFeatures == true
-            ? 'https://github.com/dart-lang/webdev/issues/2566'
-            : null,
       );
 
       test(
@@ -1789,9 +1783,6 @@ void runTests({
                 .having((instance) => instance.kind, 'kind', 'Bool'),
           );
         },
-        skip: moduleFormat == ModuleFormat.ddc && canaryFeatures == true
-            ? 'https://github.com/dart-lang/webdev/issues/2566'
-            : null,
       );
 
       test(
@@ -1817,9 +1808,6 @@ void runTests({
                 .having((instance) => instance.kind, 'kind', 'Double'),
           );
         },
-        skip: moduleFormat == ModuleFormat.ddc && canaryFeatures == true
-            ? 'https://github.com/dart-lang/webdev/issues/2566'
-            : null,
       );
 
       test(
@@ -1845,9 +1833,6 @@ void runTests({
                 .having((instance) => instance.kind, 'kind', 'String'),
           );
         },
-        skip: moduleFormat == ModuleFormat.ddc && canaryFeatures == true
-            ? 'https://github.com/dart-lang/webdev/issues/2566'
-            : null,
       );
     });