diff --git a/README.rst b/README.rst
index c147abf4f..725bb4fe8 100644
--- a/README.rst
+++ b/README.rst
@@ -45,7 +45,7 @@ In addition to the built-in panels, a number of third-party panels are
 contributed by the community.
 
 The current stable version of the Debug Toolbar is 3.2.4. It works on
-Django ≥ 2.2.
+Django ≥ 3.2.
 
 Documentation, including installation and configuration instructions, is
 available at https://django-debug-toolbar.readthedocs.io/.
diff --git a/debug_toolbar/__init__.py b/debug_toolbar/__init__.py
index 401de16c1..7dbb53bd5 100644
--- a/debug_toolbar/__init__.py
+++ b/debug_toolbar/__init__.py
@@ -1,5 +1,3 @@
-import django
-
 from debug_toolbar.urls import app_name
 
 __all__ = ["VERSION"]
@@ -12,6 +10,3 @@
 # Code that discovers files or modules in INSTALLED_APPS imports this module.
 
 urls = "debug_toolbar.urls", app_name
-
-if django.VERSION < (3, 2):
-    default_app_config = "debug_toolbar.apps.DebugToolbarConfig"
diff --git a/debug_toolbar/management/commands/debugsqlshell.py b/debug_toolbar/management/commands/debugsqlshell.py
index ba0f32463..577126ecd 100644
--- a/debug_toolbar/management/commands/debugsqlshell.py
+++ b/debug_toolbar/management/commands/debugsqlshell.py
@@ -1,11 +1,10 @@
 from time import time
 
-import django
 import sqlparse
 from django.core.management.commands.shell import Command
 from django.db import connection
 
-if connection.vendor == "postgresql" and django.VERSION >= (3, 0, 0):
+if connection.vendor == "postgresql":
     from django.db.backends.postgresql import base as base_module
 else:
     from django.db.backends import utils as base_module
diff --git a/debug_toolbar/panels/cache.py b/debug_toolbar/panels/cache.py
index 9f998b18f..19ec7b583 100644
--- a/debug_toolbar/panels/cache.py
+++ b/debug_toolbar/panels/cache.py
@@ -8,15 +8,9 @@
 except ImportError:
     ConnectionProxy = None
 
-import django
 from django.conf import settings
 from django.core import cache
-from django.core.cache import (
-    DEFAULT_CACHE_ALIAS,
-    CacheHandler,
-    cache as original_cache,
-    caches as original_caches,
-)
+from django.core.cache import DEFAULT_CACHE_ALIAS, CacheHandler
 from django.core.cache.backends.base import BaseCache
 from django.dispatch import Signal
 from django.middleware import cache as middleware_cache
@@ -141,26 +135,17 @@ def decr_version(self, *args, **kwargs):
         return self.cache.decr_version(*args, **kwargs)
 
 
-if django.VERSION < (3, 2):
+class CacheHandlerPatch(CacheHandler):
+    def __init__(self, settings=None):
+        self._djdt_wrap = True
+        super().__init__(settings=settings)
 
-    class CacheHandlerPatch(CacheHandler):
-        def __getitem__(self, alias):
-            actual_cache = super().__getitem__(alias)
+    def create_connection(self, alias):
+        actual_cache = super().create_connection(alias)
+        if self._djdt_wrap:
             return CacheStatTracker(actual_cache)
-
-else:
-
-    class CacheHandlerPatch(CacheHandler):
-        def __init__(self, settings=None):
-            self._djdt_wrap = True
-            super().__init__(settings=settings)
-
-        def create_connection(self, alias):
-            actual_cache = super().create_connection(alias)
-            if self._djdt_wrap:
-                return CacheStatTracker(actual_cache)
-            else:
-                return actual_cache
+        else:
+            return actual_cache
 
 
 middleware_cache.caches = CacheHandlerPatch()
@@ -268,40 +253,26 @@ def title(self):
         )
 
     def enable_instrumentation(self):
-        if django.VERSION < (3, 2):
-            if isinstance(middleware_cache.caches, CacheHandlerPatch):
-                cache.caches = middleware_cache.caches
-            else:
-                cache.caches = CacheHandlerPatch()
-        else:
-            for alias in cache.caches:
-                if not isinstance(cache.caches[alias], CacheStatTracker):
-                    cache.caches[alias] = CacheStatTracker(cache.caches[alias])
+        for alias in cache.caches:
+            if not isinstance(cache.caches[alias], CacheStatTracker):
+                cache.caches[alias] = CacheStatTracker(cache.caches[alias])
 
-            if not isinstance(middleware_cache.caches, CacheHandlerPatch):
-                middleware_cache.caches = cache.caches
+        if not isinstance(middleware_cache.caches, CacheHandlerPatch):
+            middleware_cache.caches = cache.caches
 
         # Wrap the patched cache inside Django's ConnectionProxy
         if ConnectionProxy:
             cache.cache = ConnectionProxy(cache.caches, DEFAULT_CACHE_ALIAS)
 
     def disable_instrumentation(self):
-        if django.VERSION < (3, 2):
-            cache.caches = original_caches
-            cache.cache = original_cache
-            # While it can be restored to the original, any views that were
-            # wrapped with the cache_page decorator will continue to use a
-            # monkey patched cache.
-            middleware_cache.caches = original_caches
-        else:
-            for alias in cache.caches:
-                if isinstance(cache.caches[alias], CacheStatTracker):
-                    cache.caches[alias] = cache.caches[alias].cache
-            if ConnectionProxy:
-                cache.cache = ConnectionProxy(cache.caches, DEFAULT_CACHE_ALIAS)
-            # While it can be restored to the original, any views that were
-            # wrapped with the cache_page decorator will continue to use a
-            # monkey patched cache.
+        for alias in cache.caches:
+            if isinstance(cache.caches[alias], CacheStatTracker):
+                cache.caches[alias] = cache.caches[alias].cache
+        if ConnectionProxy:
+            cache.cache = ConnectionProxy(cache.caches, DEFAULT_CACHE_ALIAS)
+        # While it can be restored to the original, any views that were
+        # wrapped with the cache_page decorator will continue to use a
+        # monkey patched cache.
 
     def generate_stats(self, request, response):
         self.record_stats(
diff --git a/debug_toolbar/panels/settings.py b/debug_toolbar/panels/settings.py
index 85a92788e..37bba8727 100644
--- a/debug_toolbar/panels/settings.py
+++ b/debug_toolbar/panels/settings.py
@@ -1,17 +1,12 @@
 from collections import OrderedDict
 
-import django
 from django.conf import settings
 from django.utils.translation import gettext_lazy as _
+from django.views.debug import get_default_exception_reporter_filter
 
 from debug_toolbar.panels import Panel
 
-if django.VERSION >= (3, 1):
-    from django.views.debug import get_default_exception_reporter_filter
-
-    get_safe_settings = get_default_exception_reporter_filter().get_safe_settings
-else:
-    from django.views.debug import get_safe_settings
+get_safe_settings = get_default_exception_reporter_filter().get_safe_settings
 
 
 class SettingsPanel(Panel):
diff --git a/docs/changes.rst b/docs/changes.rst
index f953ce498..a24be5ce7 100644
--- a/docs/changes.rst
+++ b/docs/changes.rst
@@ -4,7 +4,7 @@ Change log
 Next version
 ------------
 
-* Removed support for Django 3.1.
+* Removed support for Django < 3.2.
 
 3.2.4 (2021-12-15)
 ------------------
diff --git a/setup.cfg b/setup.cfg
index 2f4afdc90..4511d3c1c 100644
--- a/setup.cfg
+++ b/setup.cfg
@@ -14,7 +14,6 @@ classifiers =
     Development Status :: 5 - Production/Stable
     Environment :: Web Environment
     Framework :: Django
-    Framework :: Django :: 2.2
     Framework :: Django :: 3.2
     Framework :: Django :: 4.0
     Intended Audience :: Developers
@@ -33,7 +32,7 @@ classifiers =
 [options]
 python_requires = >=3.6
 install_requires =
-    Django >= 2.2
+    Django >= 3.2
     sqlparse >= 0.2.0
 packages = find:
 include_package_data = true
diff --git a/tests/commands/test_debugsqlshell.py b/tests/commands/test_debugsqlshell.py
index 9520d0dd8..9939c5ca9 100644
--- a/tests/commands/test_debugsqlshell.py
+++ b/tests/commands/test_debugsqlshell.py
@@ -1,14 +1,13 @@
 import io
 import sys
 
-import django
 from django.contrib.auth.models import User
 from django.core import management
 from django.db import connection
 from django.test import TestCase
 from django.test.utils import override_settings
 
-if connection.vendor == "postgresql" and django.VERSION >= (3, 0, 0):
+if connection.vendor == "postgresql":
     from django.db.backends.postgresql import base as base_module
 else:
     from django.db.backends import utils as base_module
diff --git a/tests/models.py b/tests/models.py
index 0c070a7f2..95696020a 100644
--- a/tests/models.py
+++ b/tests/models.py
@@ -1,5 +1,6 @@
 from django.conf import settings
 from django.db import models
+from django.db.models import JSONField
 
 
 class NonAsciiRepr:
@@ -11,19 +12,8 @@ class Binary(models.Model):
     field = models.BinaryField()
 
 
-try:
-    from django.db.models import JSONField
-except ImportError:  # Django<3.1
-    try:
-        from django.contrib.postgres.fields import JSONField
-    except ImportError:  # psycopg2 not installed
-        JSONField = None
-
-
-if JSONField:
-
-    class PostgresJSON(models.Model):
-        field = JSONField()
+class PostgresJSON(models.Model):
+    field = JSONField()
 
 
 if settings.USE_GIS:
diff --git a/tests/panels/test_sql.py b/tests/panels/test_sql.py
index 9358a2f70..d7e9759af 100644
--- a/tests/panels/test_sql.py
+++ b/tests/panels/test_sql.py
@@ -15,16 +15,7 @@
 from debug_toolbar import settings as dt_settings
 
 from ..base import BaseTestCase
-
-try:
-    from psycopg2._json import Json as PostgresJson
-except ImportError:
-    PostgresJson = None
-
-if connection.vendor == "postgresql":
-    from ..models import PostgresJSON as PostgresJSONModel
-else:
-    PostgresJSONModel = None
+from ..models import PostgresJSON
 
 
 class SQLPanelTestCase(BaseTestCase):
@@ -138,12 +129,9 @@ def test_param_conversion(self):
         # ensure query was logged
         self.assertEqual(len(self.panel._queries), 3)
 
-        if (
-            django.VERSION >= (3, 1)
-            # Django 4.1 started passing true/false back for boolean
-            # comparisons in MySQL.
-            and not (django.VERSION >= (4, 1) and connection.vendor == "mysql")
-        ):
+        # Django 4.1 started passing true/false back for boolean
+        # comparisons in MySQL.
+        if not (django.VERSION >= (4, 1) and connection.vendor == "mysql"):
             self.assertEqual(
                 tuple([q[1]["params"] for q in self.panel._queries]),
                 ('["Foo"]', "[10, 1]", '["2017-12-22 16:07:01"]'),
@@ -160,7 +148,7 @@ def test_param_conversion(self):
     def test_json_param_conversion(self):
         self.assertEqual(len(self.panel._queries), 0)
 
-        list(PostgresJSONModel.objects.filter(field__contains={"foo": "bar"}))
+        list(PostgresJSON.objects.filter(field__contains={"foo": "bar"}))
 
         response = self.panel.process_request(self.request)
         self.panel.generate_stats(self.request, response)
@@ -171,11 +159,6 @@ def test_json_param_conversion(self):
             self.panel._queries[0][1]["params"],
             '["{\\"foo\\": \\"bar\\"}"]',
         )
-        if django.VERSION < (3, 1):
-            self.assertIsInstance(
-                self.panel._queries[0][1]["raw_params"][0],
-                PostgresJson,
-            )
 
     def test_binary_param_force_text(self):
         self.assertEqual(len(self.panel._queries), 0)
diff --git a/tests/test_forms.py b/tests/test_forms.py
index 73d820fd8..6da504233 100644
--- a/tests/test_forms.py
+++ b/tests/test_forms.py
@@ -1,17 +1,11 @@
 from datetime import datetime
 
-import django
 from django import forms
 from django.test import TestCase
 
 from debug_toolbar.forms import SignedDataForm
 
-# Django 3.1 uses sha256 by default.
-SIGNATURE = (
-    "v02QBcJplEET6QXHNWejnRcmSENWlw6_RjxLTR7QG9g"
-    if django.VERSION >= (3, 1)
-    else "ukcAFUqYhUUnqT-LupnYoo-KvFg"
-)
+SIGNATURE = "v02QBcJplEET6QXHNWejnRcmSENWlw6_RjxLTR7QG9g"
 
 DATA = {"value": "foo", "date": datetime(2020, 1, 1)}
 SIGNED_DATA = f'{{"date": "2020-01-01 00:00:00", "value": "foo"}}:{SIGNATURE}'
diff --git a/tests/test_integration.py b/tests/test_integration.py
index ff6d32d9f..b76ebf875 100644
--- a/tests/test_integration.py
+++ b/tests/test_integration.py
@@ -2,7 +2,6 @@
 import re
 import unittest
 
-import django
 import html5lib
 from django.contrib.staticfiles.testing import StaticLiveServerTestCase
 from django.core import signing
@@ -444,10 +443,7 @@ def test_auth_login_view_without_redirect(self):
         self.assertEqual(response.status_code, 200)
         # The key None (without quotes) exists in the list of template
         # variables.
-        if django.VERSION < (3, 0):
-            self.assertIn("None: &#39;&#39;", response.json()["content"])
-        else:
-            self.assertIn("None: &#x27;&#x27;", response.json()["content"])
+        self.assertIn("None: &#x27;&#x27;", response.json()["content"])
 
 
 @unittest.skipIf(webdriver is None, "selenium isn't installed")
diff --git a/tox.ini b/tox.ini
index 65fea4b36..9a4a5c8d4 100644
--- a/tox.ini
+++ b/tox.ini
@@ -2,13 +2,11 @@
 envlist =
     docs
     packaging
-    py{36,37}-dj{22,32}-{sqlite,postgresql,postgis,mysql}
-    py{38,39}-dj{22,32,40,main}-{sqlite,postgresql,postgis,mysql}
-    py{310}-dj{32,40,main}-{sqlite,postgresql,postgis,mysql}
+    py{36,37}-dj{32}-{sqlite,postgresql,postgis,mysql}
+    py{38,39,310}-dj{32,40,main}-{sqlite,postgresql,postgis,mysql}
 
 [testenv]
 deps =
-    dj22: django~=2.2.17
     dj32: django~=3.2.9
     dj40: django~=4.0.0
     sqlite: mock
@@ -42,25 +40,25 @@ whitelist_externals = make
 pip_pre = True
 commands = make coverage TEST_ARGS='{posargs:tests}'
 
-[testenv:py{36,37,38,39,310}-dj{22,32,40,main}-postgresql]
+[testenv:py{36,37,38,39,310}-dj{40,main}-postgresql]
 setenv =
     {[testenv]setenv}
     DB_BACKEND = postgresql
     DB_PORT = {env:DB_PORT:5432}
 
-[testenv:py{36,37,38,39,310}-dj{22,32,40,main}-postgis]
+[testenv:py{36,37,38,39,310}-dj{32,40,main}-postgis]
 setenv =
     {[testenv]setenv}
     DB_BACKEND = postgis
     DB_PORT = {env:DB_PORT:5432}
 
-[testenv:py{36,37,38,39,310}-dj{22,32,40,main}-mysql]
+[testenv:py{36,37,38,39,310}-dj{32,40,main}-mysql]
 setenv =
     {[testenv]setenv}
     DB_BACKEND = mysql
     DB_PORT = {env:DB_PORT:3306}
 
-[testenv:py{36,37,38,39,310}-dj{22,32,40,main}-sqlite]
+[testenv:py{36,37,38,39,310}-dj{32,40,main}-sqlite]
 setenv =
     {[testenv]setenv}
     DB_BACKEND = sqlite3