diff --git a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/SubstitutedILProvider.cs b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/SubstitutedILProvider.cs
index db8bec02ff2b9c..8dce45e8fd8abf 100644
--- a/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/SubstitutedILProvider.cs
+++ b/src/coreclr/tools/aot/ILCompiler.Compiler/Compiler/SubstitutedILProvider.cs
@@ -659,6 +659,67 @@ public MethodIL GetMethodILWithInlinedSubstitutions(MethodIL method)
             return new SubstitutedMethodIL(method.GetMethodILDefinition(), newBody, newEHRegions.ToArray(), debugInfo, newStrings.ToArray());
         }
 
+        private bool TryGetMethodConstantValue(MethodDesc method, out int constant, int level = 0)
+        {
+            method = method.GetTypicalMethodDefinition();
+
+            TypeFlags returnType = method.Signature.ReturnType.UnderlyingType.Category;
+            if (returnType is < TypeFlags.Boolean or > TypeFlags.UInt32
+                || method.IsIntrinsic
+                || _nestedILProvider.GetMethodIL(method) is not MethodIL methodIL)
+            {
+                constant = 0;
+                return false;
+            }
+
+            var reader = new ILReader(methodIL.GetILBytes());
+            var opcode = reader.ReadILOpcode();
+            switch (opcode)
+            {
+                case ILOpcode.ldc_i4: constant = (int)reader.ReadILUInt32(); break;
+                case ILOpcode.ldc_i4_s: constant = (sbyte)reader.ReadILByte(); break;
+                case >= ILOpcode.ldc_i4_0 and <= ILOpcode.ldc_i4_8: constant = opcode - ILOpcode.ldc_i4_0; break;
+                case ILOpcode.ldc_i4_m1: constant = -1; break;
+
+                case ILOpcode.call:
+                {
+                    MethodDesc callee = (MethodDesc)methodIL.GetObject(reader.ReadILToken());
+                    if (reader.ReadILOpcode() != ILOpcode.ret)
+                    {
+                        constant = 0;
+                        return false;
+                    }
+
+                    BodySubstitution substitution = _substitutionProvider.GetSubstitution(method);
+                    if (substitution != null && substitution.Value is int c)
+                    {
+                        constant = c;
+                        return true;
+                    }
+
+                    if (level > 4)
+                    {
+                        constant = 0;
+                        return false;
+                    }
+
+                    return TryGetMethodConstantValue(callee, out constant, level + 1);
+                }
+
+                default:
+                    constant = 0;
+                    return false;
+            }
+
+            if (reader.ReadILOpcode() != ILOpcode.ret)
+            {
+                constant = 0;
+                return false;
+            }
+
+            return true;
+        }
+
         private bool TryGetConstantArgument(MethodIL methodIL, byte[] body, OpcodeFlags[] flags, int offset, int argIndex, out int constant)
         {
             if ((flags[offset] & OpcodeFlags.BasicBlockStart) != 0)
@@ -686,6 +747,11 @@ private bool TryGetConstantArgument(MethodIL methodIL, byte[] body, OpcodeFlags[
                             constant = (int)substitution.Value;
                             return true;
                         }
+                        if ((opcode != ILOpcode.callvirt || !method.IsVirtual)
+                            && TryGetMethodConstantValue(method, out constant))
+                        {
+                            return true;
+                        }
                         else if (method.IsIntrinsic && method.Name is "get_IsValueType" or "get_IsEnum"
                             && method.OwningType is MetadataType mdt
                             && mdt.Name == "Type" && mdt.Namespace == "System" && mdt.Module == mdt.Context.SystemModule
diff --git a/src/tests/nativeaot/SmokeTests/TrimmingBehaviors/DeadCodeElimination.cs b/src/tests/nativeaot/SmokeTests/TrimmingBehaviors/DeadCodeElimination.cs
index 2d3979ec735ee9..66e39892d27441 100644
--- a/src/tests/nativeaot/SmokeTests/TrimmingBehaviors/DeadCodeElimination.cs
+++ b/src/tests/nativeaot/SmokeTests/TrimmingBehaviors/DeadCodeElimination.cs
@@ -18,6 +18,7 @@ public static int Run()
         TestAbstractNeverDerivedWithDevirtualizedCall.Run();
         TestAbstractDerivedByUnrelatedTypeWithDevirtualizedCall.Run();
         TestUnusedDefaultInterfaceMethod.Run();
+        TestInlinedDeadBranchElimination.Run();
         TestArrayElementTypeOperations.Run();
         TestStaticVirtualMethodOptimizations.Run();
         TestTypeEquals.Run();
@@ -251,6 +252,37 @@ public static void Run()
         }
     }
 
+    class TestInlinedDeadBranchElimination
+    {
+        static int GetIntConstant() => 42;
+        static int GetIntConstantWrapper() => GetIntConstant();
+
+        class NeverReferenced1 { }
+
+        enum MyEnum { One, Two }
+
+        static MyEnum GetEnumConstant() => MyEnum.Two;
+
+        class NeverReferenced2 { }
+
+        public static void Run()
+        {
+            if (GetIntConstantWrapper() == 1)
+            {
+                Activator.CreateInstance(typeof(NeverReferenced1));
+            }
+
+            ThrowIfPresent(typeof(TestInlinedDeadBranchElimination), nameof(NeverReferenced1));
+
+            if (GetEnumConstant() == MyEnum.One)
+            {
+                Activator.CreateInstance(typeof(NeverReferenced2));
+            }
+
+            ThrowIfPresent(typeof(TestInlinedDeadBranchElimination), nameof(NeverReferenced2));
+        }
+    }
+
     class TestArrayElementTypeOperations
     {
         public static void Run()