diff --git a/packages/node-integration-tests/.gitignore b/packages/node-integration-tests/.gitignore
new file mode 100644
index 000000000000..3c3629e647f5
--- /dev/null
+++ b/packages/node-integration-tests/.gitignore
@@ -0,0 +1 @@
+node_modules
diff --git a/packages/node-integration-tests/package.json b/packages/node-integration-tests/package.json
index 002031983f52..87920c697cad 100644
--- a/packages/node-integration-tests/package.json
+++ b/packages/node-integration-tests/package.json
@@ -7,14 +7,18 @@
   },
   "private": true,
   "scripts": {
+    "clean": "rimraf -g **/node_modules",
+    "prisma:init": "(cd suites/tracing/prisma-orm && ts-node ./setup.ts)",
     "lint": "run-s lint:prettier lint:eslint",
     "lint:eslint": "eslint . --cache --cache-location '../../eslintcache/' --format stylish",
     "lint:prettier": "prettier --check \"{suites,utils}/**/*.ts\"",
     "type-check": "tsc",
+    "pretest": "run-s --silent prisma:init",
     "test": "jest --runInBand --forceExit",
     "test:watch": "yarn test --watch"
   },
   "dependencies": {
+    "@prisma/client": "^3.12.0",
     "@types/mongodb": "^3.6.20",
     "@types/mysql": "^2.15.21",
     "@types/pg": "^8.6.5",
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/docker-compose.yml b/packages/node-integration-tests/suites/tracing/prisma-orm/docker-compose.yml
new file mode 100644
index 000000000000..45caa4bb3179
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/docker-compose.yml
@@ -0,0 +1,13 @@
+version: '3.9'
+
+services:
+  db:
+    image: postgres:13
+    restart: always
+    container_name: integration-tests-prisma
+    ports:
+      - '5433:5432'
+    environment:
+      POSTGRES_USER: prisma
+      POSTGRES_PASSWORD: prisma
+      POSTGRES_DB: tests
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/package.json b/packages/node-integration-tests/suites/tracing/prisma-orm/package.json
new file mode 100644
index 000000000000..f8b24d7d0465
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/package.json
@@ -0,0 +1,22 @@
+{
+  "name": "sentry-prisma-test",
+  "version": "1.0.0",
+  "description": "",
+  "main": "index.js",
+  "engines": {
+    "node": ">=12"
+  },
+  "scripts": {
+    "db-up": "docker-compose up -d",
+    "generate": "prisma generate",
+    "migrate": "prisma migrate dev -n sentry-test",
+    "setup": "run-s --silent db-up generate migrate"
+  },
+  "keywords": [],
+  "author": "",
+  "license": "ISC",
+  "dependencies": {
+    "@prisma/client": "3.12.0",
+    "prisma": "^3.12.0"
+  }
+}
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/migrations/migration_lock.toml b/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/migrations/migration_lock.toml
new file mode 100644
index 000000000000..fbffa92c2bb7
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/migrations/migration_lock.toml
@@ -0,0 +1,3 @@
+# Please do not edit this file manually
+# It should be added in your version-control system (i.e. Git)
+provider = "postgresql"
\ No newline at end of file
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/migrations/sentry_test/migration.sql b/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/migrations/sentry_test/migration.sql
new file mode 100644
index 000000000000..8619aaceb2b0
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/migrations/sentry_test/migration.sql
@@ -0,0 +1,12 @@
+-- CreateTable
+CREATE TABLE "User" (
+    "id" SERIAL NOT NULL,
+    "createdAt" TIMESTAMP(3) NOT NULL DEFAULT CURRENT_TIMESTAMP,
+    "email" TEXT NOT NULL,
+    "name" TEXT,
+
+    CONSTRAINT "User_pkey" PRIMARY KEY ("id")
+);
+
+-- CreateIndex
+CREATE UNIQUE INDEX "User_email_key" ON "User"("email");
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/schema.prisma b/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/schema.prisma
new file mode 100644
index 000000000000..4363c97738ee
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/prisma/schema.prisma
@@ -0,0 +1,15 @@
+datasource db {
+  url      = "postgresql://prisma:prisma@localhost:5433/tests"
+  provider = "postgresql"
+}
+
+generator client {
+  provider = "prisma-client-js"
+}
+
+model User {
+  id        Int      @id @default(autoincrement())
+  createdAt DateTime @default(now())
+  email     String   @unique
+  name      String?
+}
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/scenario.ts b/packages/node-integration-tests/suites/tracing/prisma-orm/scenario.ts
new file mode 100644
index 000000000000..047166a9e136
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/scenario.ts
@@ -0,0 +1,48 @@
+/* eslint-disable @typescript-eslint/no-unsafe-member-access */
+import { PrismaClient } from '@prisma/client';
+import * as Sentry from '@sentry/node';
+import * as Tracing from '@sentry/tracing';
+import { randomBytes } from 'crypto';
+
+const client = new PrismaClient();
+
+Sentry.init({
+  dsn: 'https://public@dsn.ingest.sentry.io/1337',
+  release: '1.0',
+  tracesSampleRate: 1.0,
+  integrations: [new Tracing.Integrations.Prisma({ client })],
+});
+
+async function run(): Promise<void> {
+  const transaction = Sentry.startTransaction({
+    name: 'Test Transaction',
+    op: 'transaction',
+  });
+
+  Sentry.configureScope(scope => {
+    scope.setSpan(transaction);
+  });
+
+  try {
+    await client.user.create({
+      data: {
+        name: 'Tilda',
+        email: `tilda_${randomBytes(4).toString('hex')}@sentry.io`,
+      },
+    });
+
+    await client.user.findMany();
+
+    await client.user.deleteMany({
+      where: {
+        email: {
+          contains: 'sentry.io',
+        },
+      },
+    });
+  } finally {
+    if (transaction) transaction.finish();
+  }
+}
+
+void run();
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/setup.ts b/packages/node-integration-tests/suites/tracing/prisma-orm/setup.ts
new file mode 100755
index 000000000000..3c40d12f7337
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/setup.ts
@@ -0,0 +1,16 @@
+import { parseSemver } from '@sentry/utils';
+import { execSync } from 'child_process';
+
+const NODE_VERSION = parseSemver(process.versions.node);
+
+if (NODE_VERSION.major && NODE_VERSION.major < 12) {
+  // eslint-disable-next-line no-console
+  console.warn(`Skipping Prisma tests on Node: ${NODE_VERSION.major}`);
+  process.exit(0);
+}
+
+try {
+  execSync('yarn && yarn setup');
+} catch (_) {
+  process.exit(1);
+}
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/test.ts b/packages/node-integration-tests/suites/tracing/prisma-orm/test.ts
new file mode 100644
index 000000000000..91e6f39da889
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/test.ts
@@ -0,0 +1,17 @@
+import { assertSentryTransaction, conditionalTest, getEnvelopeRequest, runServer } from '../../../utils';
+
+conditionalTest({ min: 12 })('Prisma ORM Integration', () => {
+  test('should instrument Prisma client for tracing.', async () => {
+    const url = await runServer(__dirname);
+    const envelope = await getEnvelopeRequest(url);
+
+    assertSentryTransaction(envelope[2], {
+      transaction: 'Test Transaction',
+      spans: [
+        { description: 'User create', op: 'db.prisma' },
+        { description: 'User findMany', op: 'db.prisma' },
+        { description: 'User deleteMany', op: 'db.prisma' },
+      ],
+    });
+  });
+});
diff --git a/packages/node-integration-tests/suites/tracing/prisma-orm/yarn.lock b/packages/node-integration-tests/suites/tracing/prisma-orm/yarn.lock
new file mode 100644
index 000000000000..d228adebd621
--- /dev/null
+++ b/packages/node-integration-tests/suites/tracing/prisma-orm/yarn.lock
@@ -0,0 +1,27 @@
+# THIS IS AN AUTOGENERATED FILE. DO NOT EDIT THIS FILE DIRECTLY.
+# yarn lockfile v1
+
+
+"@prisma/client@3.12.0":
+  version "3.12.0"
+  resolved "https://registry.yarnpkg.com/@prisma/client/-/client-3.12.0.tgz#a0eb49ffea5c128dd11dffb896d7139a60073d12"
+  integrity sha512-4NEQjUcWja/NVBvfuDFscWSk1/rXg3+wj+TSkqXCb1tKlx/bsUE00rxsvOvGg7VZ6lw1JFpGkwjwmsOIc4zvQw==
+  dependencies:
+    "@prisma/engines-version" "3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980"
+
+"@prisma/engines-version@3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980":
+  version "3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980"
+  resolved "https://registry.yarnpkg.com/@prisma/engines-version/-/engines-version-3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980.tgz#829ca3d9d0d92555f44644606d4edfd45b2f5886"
+  integrity sha512-o+jo8d7ZEiVpcpNWUDh3fj2uPQpBxl79XE9ih9nkogJbhw6P33274SHnqheedZ7PyvPIK/mvU8MLNYgetgXPYw==
+
+"@prisma/engines@3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980":
+  version "3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980"
+  resolved "https://registry.yarnpkg.com/@prisma/engines/-/engines-3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980.tgz#e52e364084c4d05278f62768047b788665e64a45"
+  integrity sha512-zULjkN8yhzS7B3yeEz4aIym4E2w1ChrV12i14pht3ePFufvsAvBSoZ+tuXMvfSoNTgBS5E4bolRzLbMmbwkkMQ==
+
+prisma@^3.12.0:
+  version "3.12.0"
+  resolved "https://registry.yarnpkg.com/prisma/-/prisma-3.12.0.tgz#9675e0e72407122759d3eadcb6d27cdccd3497bd"
+  integrity sha512-ltCMZAx1i0i9xuPM692Srj8McC665h6E5RqJom999sjtVSccHSD8Z+HSdBN2183h9PJKvC5dapkn78dd0NWMBg==
+  dependencies:
+    "@prisma/engines" "3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980"
diff --git a/packages/tracing/src/integrations/node/prisma.ts b/packages/tracing/src/integrations/node/prisma.ts
index e70fce9f0f60..3aa7a07f4da3 100644
--- a/packages/tracing/src/integrations/node/prisma.ts
+++ b/packages/tracing/src/integrations/node/prisma.ts
@@ -38,6 +38,10 @@ interface PrismaClient {
   $use: (cb: PrismaMiddleware) => void;
 }
 
+function isValidPrismaClient(possibleClient: unknown): possibleClient is PrismaClient {
+  return possibleClient && !!(possibleClient as PrismaClient)['$use'];
+}
+
 /** Tracing integration for @prisma/client package */
 export class Prisma implements Integration {
   /**
@@ -58,8 +62,14 @@ export class Prisma implements Integration {
   /**
    * @inheritDoc
    */
-  public constructor(options: { client?: PrismaClient } = {}) {
-    this._client = options.client;
+  public constructor(options: { client?: unknown } = {}) {
+    if (isValidPrismaClient(options.client)) {
+      this._client = options.client;
+    } else {
+      logger.warn(
+        `Unsupported Prisma client provided to PrismaIntegration. Provided client: ${JSON.stringify(options.client)}`,
+      );
+    }
   }
 
   /**
@@ -71,7 +81,7 @@ export class Prisma implements Integration {
       return;
     }
 
-    this._client.$use((params: PrismaMiddlewareParams, next: (params: PrismaMiddlewareParams) => Promise<unknown>) => {
+    this._client.$use((params, next: (params: PrismaMiddlewareParams) => Promise<unknown>) => {
       const scope = getCurrentHub().getScope();
       const parentSpan = scope?.getSpan();
 
diff --git a/yarn.lock b/yarn.lock
index 6b21e6baa196..f6ba304563d7 100644
--- a/yarn.lock
+++ b/yarn.lock
@@ -4079,6 +4079,18 @@
   resolved "https://registry.yarnpkg.com/@polka/url/-/url-1.0.0-next.12.tgz#431ec342a7195622f86688bbda82e3166ce8cb28"
   integrity sha512-6RglhutqrGFMO1MNUXp95RBuYIuc8wTnMAV5MUhLmjTOy78ncwOw7RgeQ/HeymkKXRhZd0s2DNrM1rL7unk3MQ==
 
+"@prisma/client@^3.12.0":
+  version "3.12.0"
+  resolved "https://registry.yarnpkg.com/@prisma/client/-/client-3.12.0.tgz#a0eb49ffea5c128dd11dffb896d7139a60073d12"
+  integrity sha512-4NEQjUcWja/NVBvfuDFscWSk1/rXg3+wj+TSkqXCb1tKlx/bsUE00rxsvOvGg7VZ6lw1JFpGkwjwmsOIc4zvQw==
+  dependencies:
+    "@prisma/engines-version" "3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980"
+
+"@prisma/engines-version@3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980":
+  version "3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980"
+  resolved "https://registry.yarnpkg.com/@prisma/engines-version/-/engines-version-3.12.0-37.22b822189f46ef0dc5c5b503368d1bee01213980.tgz#829ca3d9d0d92555f44644606d4edfd45b2f5886"
+  integrity sha512-o+jo8d7ZEiVpcpNWUDh3fj2uPQpBxl79XE9ih9nkogJbhw6P33274SHnqheedZ7PyvPIK/mvU8MLNYgetgXPYw==
+
 "@protobufjs/aspromise@^1.1.1", "@protobufjs/aspromise@^1.1.2":
   version "1.1.2"
   resolved "https://registry.yarnpkg.com/@protobufjs/aspromise/-/aspromise-1.1.2.tgz#9b8b0cc663d669a7d8f6f5d0893a14d348f30fbf"