diff --git a/setup.py b/setup.py
index 7e9cd2ed08..358cc0ed13 100644
--- a/setup.py
+++ b/setup.py
@@ -275,7 +275,7 @@
         ),
         "google-auth >= 2.14.1, <3.0.0dev",
         "proto-plus >= 1.22.3, <2.0.0dev",
-        "protobuf>=3.20.2,<6.0.0dev,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
+        "protobuf>=3.20.2,<7.0.0dev,!=4.21.0,!=4.21.1,!=4.21.2,!=4.21.3,!=4.21.4,!=4.21.5",
         "packaging >= 14.3",
         "google-cloud-storage >= 1.32.0, < 3.0.0dev",
         "google-cloud-bigquery >= 1.15.0, < 4.0.0dev, !=3.20.0",