diff --git a/gax-java/gax/src/main/java/com/google/api/gax/rpc/EndpointContext.java b/gax-java/gax/src/main/java/com/google/api/gax/rpc/EndpointContext.java
index 2db7361e3a..daf1246df6 100644
--- a/gax-java/gax/src/main/java/com/google/api/gax/rpc/EndpointContext.java
+++ b/gax-java/gax/src/main/java/com/google/api/gax/rpc/EndpointContext.java
@@ -309,6 +309,16 @@ private String determineEndpoint() throws IOException {
     /** Determine if S2A can be used */
     @VisibleForTesting
     boolean shouldUseS2A() {
+      // If running on windows or macos intel, skip S2A. S2A has runtime
+      // dependency on netty-tcnative which is dropping support on these platforms.
+      // https://github.com/netty/netty-tcnative/issues/898
+      // https://github.com/netty/netty-tcnative/issues/897
+      if (System.getProperty("os.name").contains("Windows")
+          || (System.getProperty("os.name").contains("OS X")
+              && System.getProperty("os.arch").contains("x86_64"))) {
+        return false;
+      }
+
       // If mTLS endpoint is not available, skip S2A
       if (Strings.isNullOrEmpty(mtlsEndpoint())) {
         return false;