diff --git a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
index b0771ffcc38a8..c780704a6b128 100644
--- a/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
+++ b/llvm/lib/Transforms/InstCombine/InstCombineCompares.cpp
@@ -5015,6 +5015,20 @@ Instruction *InstCombinerImpl::foldICmpBinOp(ICmpInst &I,
     }
   }
 
+  // (icmp eq/ne (X, -P2), INT_MIN)
+  //	-> (icmp slt/sge X, INT_MIN + P2)
+  if (ICmpInst::isEquality(Pred) && BO0 &&
+      match(I.getOperand(1), m_SignMask())) {
+    Value *X;
+    if (match(BO0, m_And(m_Value(X), m_NegatedPower2OrZero()))) {
+      // Will Constant fold.
+      Value *NewC = Builder.CreateSub(I.getOperand(1), BO0->getOperand(1));
+      return new ICmpInst(Pred == ICmpInst::ICMP_EQ ? ICmpInst::ICMP_SLT
+                                                    : ICmpInst::ICMP_SGE,
+                          X, NewC);
+    }
+  }
+
   {
     // Similar to above: an unsigned overflow comparison may use offset + mask:
     // ((Op1 + C) & C) u<  Op1 --> Op1 != 0
diff --git a/llvm/test/Transforms/InstCombine/icmp-signmask.ll b/llvm/test/Transforms/InstCombine/icmp-signmask.ll
new file mode 100644
index 0000000000000..5424f7d7e8021
--- /dev/null
+++ b/llvm/test/Transforms/InstCombine/icmp-signmask.ll
@@ -0,0 +1,54 @@
+; NOTE: Assertions have been autogenerated by utils/update_test_checks.py
+; RUN: opt < %s -passes=instcombine -S | FileCheck %s
+
+define i1 @cmp_x_and_negp2_with_eq(i8 %x) {
+; CHECK-LABEL: @cmp_x_and_negp2_with_eq(
+; CHECK-NEXT:    [[R:%.*]] = icmp slt i8 [[X:%.*]], -126
+; CHECK-NEXT:    ret i1 [[R]]
+;
+  %andx = and i8 %x, -2
+  %r = icmp eq i8 %andx, 128
+  ret i1 %r
+}
+
+define i1 @cmp_x_and_negp2_with_eq_fail_not_signmask(i8 %x) {
+; CHECK-LABEL: @cmp_x_and_negp2_with_eq_fail_not_signmask(
+; CHECK-NEXT:    [[ANDX:%.*]] = and i8 [[X:%.*]], -2
+; CHECK-NEXT:    [[R:%.*]] = icmp eq i8 [[ANDX]], -124
+; CHECK-NEXT:    ret i1 [[R]]
+;
+  %andx = and i8 %x, -2
+  %r = icmp eq i8 %andx, 132
+  ret i1 %r
+}
+
+define <2 x i1> @cmp_x_and_negp2_with_ne(<2 x i8> %x) {
+; CHECK-LABEL: @cmp_x_and_negp2_with_ne(
+; CHECK-NEXT:    [[R:%.*]] = icmp sgt <2 x i8> [[X:%.*]], <i8 -121, i8 -113>
+; CHECK-NEXT:    ret <2 x i1> [[R]]
+;
+  %andx = and <2 x i8> %x, <i8 -8, i8 -16>
+  %r = icmp ne <2 x i8> %andx, <i8 128, i8 128>
+  ret <2 x i1> %r
+}
+
+define <2 x i1> @cmp_x_and_negp2_with_ne_or_z(<2 x i8> %x) {
+; CHECK-LABEL: @cmp_x_and_negp2_with_ne_or_z(
+; CHECK-NEXT:    [[R:%.*]] = icmp sge <2 x i8> [[X:%.*]], <i8 -128, i8 -112>
+; CHECK-NEXT:    ret <2 x i1> [[R]]
+;
+  %andx = and <2 x i8> %x, <i8 0, i8 -16>
+  %r = icmp ne <2 x i8> %andx, <i8 128, i8 128>
+  ret <2 x i1> %r
+}
+
+define <2 x i1> @cmp_x_and_negp2_with_ne_fail_not_p2(<2 x i8> %x) {
+; CHECK-LABEL: @cmp_x_and_negp2_with_ne_fail_not_p2(
+; CHECK-NEXT:    [[ANDX:%.*]] = and <2 x i8> [[X:%.*]], <i8 -8, i8 -15>
+; CHECK-NEXT:    [[R:%.*]] = icmp ne <2 x i8> [[ANDX]], <i8 -128, i8 -128>
+; CHECK-NEXT:    ret <2 x i1> [[R]]
+;
+  %andx = and <2 x i8> %x, <i8 -8, i8 -15>
+  %r = icmp ne <2 x i8> %andx, <i8 128, i8 128>
+  ret <2 x i1> %r
+}
diff --git a/llvm/test/Transforms/InstCombine/icmp.ll b/llvm/test/Transforms/InstCombine/icmp.ll
index ecf21b8a42cf5..17ed64b6e04d9 100644
--- a/llvm/test/Transforms/InstCombine/icmp.ll
+++ b/llvm/test/Transforms/InstCombine/icmp.ll
@@ -1116,8 +1116,7 @@ define i1 @test53(i32 %a, i32 %b) {
 
 define i1 @test54(i8 %a) {
 ; CHECK-LABEL: @test54(
-; CHECK-NEXT:    [[TMP1:%.*]] = and i8 [[A:%.*]], -64
-; CHECK-NEXT:    [[RET:%.*]] = icmp eq i8 [[TMP1]], -128
+; CHECK-NEXT:    [[RET:%.*]] = icmp slt i8 [[A:%.*]], -64
 ; CHECK-NEXT:    ret i1 [[RET]]
 ;
   %ext = zext i8 %a to i32