diff --git a/AutoDuck/py2d.py b/AutoDuck/py2d.py
index ce74e9c95c..7b3f641efe 100644
--- a/AutoDuck/py2d.py
+++ b/AutoDuck/py2d.py
@@ -106,11 +106,11 @@ def build_module(fp, mod_name):
             continue
         if hasattr(ob, "__module__") and ob.__module__ != mod_name:
             continue
-        if type(ob) in (type, type):
+        if type(ob) == type:
             classes.append(BuildInfo(name, ob))
-        elif type(ob) == types.FunctionType:
+        elif isinstance(ob, types.FunctionType):
             functions.append(BuildInfo(name, ob))
-        elif name.upper() == name and type(ob) in (int, str):
+        elif name.upper() == name and isinstance(ob, (int, str)):
             constants.append((name, ob))
     info = BuildInfo(mod_name, mod)
     Print("// @module %s|%s" % (mod_name, format_desc(info.desc)), file=fp)
@@ -169,7 +169,7 @@ def build_module(fp, mod_name):
 
     for name, val in constants:
         desc = "%s = %r" % (name, val)
-        if type(val) in (int, int):
+        if isinstance(val, int):
             desc += " (0x%x)" % (val,)
         Print("// @const %s|%s|%s" % (mod_name, name, desc), file=fp)
 
diff --git a/Pythonwin/pywin/Demos/dlgtest.py b/Pythonwin/pywin/Demos/dlgtest.py
index 8dcb0e5efa..acef880176 100644
--- a/Pythonwin/pywin/Demos/dlgtest.py
+++ b/Pythonwin/pywin/Demos/dlgtest.py
@@ -51,7 +51,7 @@ def OnNotify(self, controlid, code):
     # Simply increment the value in the text box.
     def KillFocus(self, msg):
         self.counter = self.counter + 1
-        if self.edit != None:
+        if self.edit is not None:
             self.edit.SetWindowText(str(self.counter))
 
     # Called when the dialog box is terminating...
diff --git a/Pythonwin/pywin/debugger/__init__.py b/Pythonwin/pywin/debugger/__init__.py
index 5f41960d36..31bb76b59c 100644
--- a/Pythonwin/pywin/debugger/__init__.py
+++ b/Pythonwin/pywin/debugger/__init__.py
@@ -123,7 +123,7 @@ def post_mortem(t=None):
     # No idea why I need to settrace to None - it should have been reset by now?
     sys.settrace(None)
     p.reset()
-    while t.tb_next != None:
+    while t.tb_next is not None:
         t = t.tb_next
     p.bAtPostMortem = 1
     p.prep_run(None)
diff --git a/Pythonwin/pywin/debugger/debugger.py b/Pythonwin/pywin/debugger/debugger.py
index 4acf9bc4d2..7f21840513 100644
--- a/Pythonwin/pywin/debugger/debugger.py
+++ b/Pythonwin/pywin/debugger/debugger.py
@@ -751,7 +751,7 @@ def run(self, cmd, globals=None, locals=None, start_stepping=1):
             self.reset()
             self.prep_run(cmd)
             sys.settrace(self.trace_dispatch)
-            if type(cmd) != types.CodeType:
+            if not isinstance(cmd, types.CodeType):
                 cmd = cmd + "\n"
             try:
                 try:
diff --git a/Pythonwin/pywin/dialogs/login.py b/Pythonwin/pywin/dialogs/login.py
index 2a3295693e..7ab3fd4e54 100644
--- a/Pythonwin/pywin/dialogs/login.py
+++ b/Pythonwin/pywin/dialogs/login.py
@@ -141,7 +141,7 @@ def GetPassword(title="Password", password=""):
     if len(sys.argv) > 2:
         def_userid = sys.argv[2]
     userid, password = GetLogin(title, def_user)
-    if userid == password == None:
+    if userid == password is None:
         print("User pressed Cancel")
     else:
         print("User ID: ", userid)
diff --git a/Pythonwin/pywin/framework/app.py b/Pythonwin/pywin/framework/app.py
index f994f99f91..b582423072 100644
--- a/Pythonwin/pywin/framework/app.py
+++ b/Pythonwin/pywin/framework/app.py
@@ -411,7 +411,7 @@ def Win32RawInput(prompt=None):
     if prompt is None:
         prompt = ""
     ret = dialog.GetSimpleInput(prompt)
-    if ret == None:
+    if ret is None:
         raise KeyboardInterrupt("operation cancelled")
     return ret
 
diff --git a/Pythonwin/pywin/framework/mdi_pychecker.py b/Pythonwin/pywin/framework/mdi_pychecker.py
index c89f33b9b9..6ae57606a2 100644
--- a/Pythonwin/pywin/framework/mdi_pychecker.py
+++ b/Pythonwin/pywin/framework/mdi_pychecker.py
@@ -137,11 +137,11 @@ def __delslice__(self, lo, hi):
         del self.dirs[lo:hi]
 
     def __add__(self, other):
-        if type(other) == type(self) or type(other) == type([]):
+        if isinstance(other, (dirpath, list)):
             return self.dirs + other.dirs
 
     def __radd__(self, other):
-        if type(other) == type(self) or type(other) == type([]):
+        if isinstance(other, (dirpath, list)):
             return other.dirs + self.dirs
 
 
@@ -319,7 +319,7 @@ def idleHandler(self, handler, count):
         import time
 
         time.sleep(0.001)
-        if self.result != None:
+        if self.result is not None:
             win32ui.GetApp().DeleteIdleHandler(self.idleHandler)
             return 0
         return 1  # more
@@ -389,7 +389,7 @@ def _inactive_idleHandler(self, handler, count):
             lines = open(f, "r").readlines()
             for i in range(len(lines)):
                 line = lines[i]
-                if self.pat.search(line) != None:
+                if self.pat.search(line) is not None:
                     self.GetFirstView().Append(f + "(" + repr(i + 1) + ") " + line)
         else:
             self.fndx = -1
diff --git a/Pythonwin/pywin/framework/sgrepmdi.py b/Pythonwin/pywin/framework/sgrepmdi.py
index b7d938bbb3..d1007a197b 100644
--- a/Pythonwin/pywin/framework/sgrepmdi.py
+++ b/Pythonwin/pywin/framework/sgrepmdi.py
@@ -120,11 +120,11 @@ def __delslice__(self, lo, hi):
         del self.dirs[lo:hi]
 
     def __add__(self, other):
-        if type(other) == type(self) or type(other) == type([]):
+        if isinstance(other, (dirpath, list)):
             return self.dirs + other.dirs
 
     def __radd__(self, other):
-        if type(other) == type(self) or type(other) == type([]):
+        if isinstance(other, (dirpath, list)):
             return other.dirs + self.dirs
 
 
@@ -302,7 +302,7 @@ def SearchFile(self, handler, count):
                 lines = open(f, "r").readlines()
                 for i in range(len(lines)):
                     line = lines[i]
-                    if self.pat.search(line) != None:
+                    if self.pat.search(line) is not None:
                         self.GetFirstView().Append(f + "(" + repr(i + 1) + ") " + line)
         else:
             self.fndx = -1
diff --git a/Pythonwin/pywin/framework/winout.py b/Pythonwin/pywin/framework/winout.py
index e78e959a9a..a55a13e374 100644
--- a/Pythonwin/pywin/framework/winout.py
+++ b/Pythonwin/pywin/framework/winout.py
@@ -129,7 +129,7 @@ def OnRClick(self, params):
         paramsList = self.GetRightMenuItems()
         menu = win32ui.CreatePopupMenu()
         for appendParams in paramsList:
-            if type(appendParams) != type(()):
+            if not isinstance(appendParams, tuple):
                 appendParams = (appendParams,)
             menu.AppendMenu(*appendParams)
         menu.TrackPopupMenu(params[5])  # track at mouse position.
@@ -377,7 +377,7 @@ def __init__(
         self.title = title
         self.bCreating = 0
         self.interruptCount = 0
-        if type(defSize) == type(""):  # is a string - maintain size pos from ini file.
+        if isinstance(defSize, str):  # maintain size pos from ini file.
             self.iniSizeSection = defSize
             self.defSize = app.LoadWindowSize(defSize)
             self.loadedSize = self.defSize
diff --git a/Pythonwin/pywin/mfc/dialog.py b/Pythonwin/pywin/mfc/dialog.py
index 25fe13635b..6e528d9b6a 100644
--- a/Pythonwin/pywin/mfc/dialog.py
+++ b/Pythonwin/pywin/mfc/dialog.py
@@ -13,9 +13,9 @@
 
 def dllFromDll(dllid):
     "given a 'dll' (maybe a dll, filename, etc), return a DLL object"
-    if dllid == None:
+    if dllid is None:
         return None
-    elif type("") == type(dllid):
+    elif isinstance(dllid, str):
         return win32ui.LoadLibrary(dllid)
     else:
         try:
@@ -33,7 +33,7 @@ def __init__(self, id, dllid=None):
         dllid may be None, a dll object, or a string with a dll name"""
         # must take a reference to the DLL until InitDialog.
         self.dll = dllFromDll(dllid)
-        if type(id) == type([]):  # a template
+        if isinstance(id, list):  # a template
             dlg = win32ui.CreateDialogIndirect(id)
         else:
             dlg = win32ui.CreateDialog(id, self.dll)
@@ -114,7 +114,7 @@ def __init__(
         dllid=None,
     ):
         self.dll = dllFromDll(dllid)
-        if type(dlgID) == type([]):  # a template
+        if isinstance(dlgID, list):  # a template
             raise TypeError("dlgID parameter must be an integer resource ID")
         dlg = win32ui.CreatePrintDialog(dlgID, printSetupOnly, flags, parent, self.dll)
         window.Wnd.__init__(self, dlg)
@@ -193,7 +193,7 @@ def __init__(self, id, dllid=None, caption=0):
         self.dll = dllFromDll(dllid)
         if self.dll:
             oldRes = win32ui.SetResource(self.dll)
-        if type(id) == type([]):
+        if isinstance(id, list):
             dlg = win32ui.CreatePropertyPageIndirect(id)
         else:
             dlg = win32ui.CreatePropertyPage(id, caption)
@@ -243,7 +243,7 @@ def AddPage(self, pages):
 
     def DoAddSinglePage(self, page):
         "Page may be page, or int ID. Assumes DLL setup"
-        if type(page) == type(0):
+        if isinstance(page, int):
             self.sheet.AddPage(win32ui.CreatePropertyPage(page))
         else:
             self.sheet.AddPage(page)
diff --git a/Pythonwin/pywin/scintilla/config.py b/Pythonwin/pywin/scintilla/config.py
index 9a1b210e9c..6f169eed37 100644
--- a/Pythonwin/pywin/scintilla/config.py
+++ b/Pythonwin/pywin/scintilla/config.py
@@ -199,7 +199,7 @@ def configure(self, editor, subsections=None):
             if ns:
                 num = 0
                 for name, func in list(ns.items()):
-                    if type(func) == types.FunctionType and name[:1] != "_":
+                    if isinstance(func, types.FunctionType) and name[:1] != "_":
                         bindings.bind(name, func)
                         num = num + 1
                 trace("Configuration Extension code loaded", num, "events")
diff --git a/Pythonwin/pywin/scintilla/control.py b/Pythonwin/pywin/scintilla/control.py
index e58ea3fa6a..9923489b8a 100644
--- a/Pythonwin/pywin/scintilla/control.py
+++ b/Pythonwin/pywin/scintilla/control.py
@@ -261,7 +261,7 @@ def SCICancel(self):
 
     # AutoComplete
     def SCIAutoCShow(self, text):
-        if type(text) in [type([]), type(())]:
+        if isinstance(text, (list, tuple)):
             text = " ".join(text)
         buff = (text + "\0").encode(default_scintilla_encoding)
         return self.SendScintilla(scintillacon.SCI_AUTOCSHOW, 0, buff)
@@ -423,7 +423,7 @@ def GetSelText(self):
         return txtBuf.tobytes()[:-1].decode(default_scintilla_encoding)
 
     def SetSel(self, start=0, end=None):
-        if type(start) == type(()):
+        if isinstance(start, tuple):
             assert (
                 end is None
             ), "If you pass a point in the first param, the second must be None"
diff --git a/Pythonwin/pywin/scintilla/formatter.py b/Pythonwin/pywin/scintilla/formatter.py
index 56100ccfcf..3687d64e00 100644
--- a/Pythonwin/pywin/scintilla/formatter.py
+++ b/Pythonwin/pywin/scintilla/formatter.py
@@ -36,7 +36,7 @@ def __init__(self, name, format, background=CLR_INVALID):
         # Default background for each style is only used when there are no
         # saved settings (generally on first startup)
         self.background = self.default_background = background
-        if type(format) == type(""):
+        if isinstance(format, str):
             self.aliased = format
             self.format = None
         else:
diff --git a/Pythonwin/pywin/tools/hierlist.py b/Pythonwin/pywin/tools/hierlist.py
index a60b732472..341532f575 100644
--- a/Pythonwin/pywin/tools/hierlist.py
+++ b/Pythonwin/pywin/tools/hierlist.py
@@ -25,11 +25,11 @@
 
 # helper to get the text of an arbitary item
 def GetItemText(item):
-    if type(item) == type(()) or type(item) == type([]):
+    if isinstance(item, (tuple, list)):
         use = item[0]
     else:
         use = item
-    if type(use) == type(""):
+    if isinstance(use, str):
         return use
     else:
         return repr(item)
@@ -185,8 +185,8 @@ def AddItem(self, parentHandle, item, hInsertAfter=commctrl.TVI_LAST):
         bitmapSel = self.GetSelectedBitmapColumn(item)
         if bitmapSel is None:
             bitmapSel = bitmapCol
-        ## if type(text) is str:
-        ##	text = text.encode("mbcs")
+        ## if isinstance(text, str):
+        ##  text = text.encode("mbcs")
         hitem = self.listControl.InsertItem(
             parentHandle,
             hInsertAfter,
diff --git a/adodbapi/adodbapi.py b/adodbapi/adodbapi.py
index 8f7c045ea7..36a2c88961 100644
--- a/adodbapi/adodbapi.py
+++ b/adodbapi/adodbapi.py
@@ -1208,7 +1208,7 @@ def setoutputsize(self, size, column=None):
 
     def _last_query(self):  # let the programmer see what query we actually used
         try:
-            if self.parameters == None:
+            if self.parameters is None:
                 ret = self.commandText
             else:
                 ret = "%s,parameters=%s" % (self.commandText, repr(self.parameters))
diff --git a/adodbapi/apibase.py b/adodbapi/apibase.py
index 50770c96ee..d16265917f 100644
--- a/adodbapi/apibase.py
+++ b/adodbapi/apibase.py
@@ -171,6 +171,7 @@ def __init__(self):  # the details will be filled in by instances
         self._ordinal_1899_12_31 = datetime.date(1899, 12, 31).toordinal() - 1
         # Use cls.types to compare if an input parameter is a datetime
         self.types = {
+            # Dynamically get the types as the methods may be overriden
             type(self.Date(2000, 1, 1)),
             type(self.Time(12, 1, 1)),
             type(self.Timestamp(2000, 1, 1, 12, 1, 1)),
@@ -444,9 +445,8 @@ def pyTypeToADOType(d):
     except KeyError:  #   The type was not defined in the pre-computed Type table
         from . import dateconverter
 
-        if (
-            tp in dateconverter.types
-        ):  # maybe it is one of our supported Date/Time types
+        # maybe it is one of our supported Date/Time types
+        if tp in dateconverter.types:
             return adc.adDate
         #  otherwise, attempt to discern the type by probing the data object itself -- to handle duck typing
         if isinstance(d, StringTypes):
diff --git a/adodbapi/remote/server.py b/adodbapi/remote/server.py
index 3cce1d8ab4..bfba3a7473 100644
--- a/adodbapi/remote/server.py
+++ b/adodbapi/remote/server.py
@@ -118,7 +118,7 @@ def unfixpickle(x):
         # for 'named' paramstyle user will pass a mapping
         newargs = {}
         for arg, val in list(x.items()):
-            if isinstance(arg, type(array.array("B"))):
+            if isinstance(arg, array.array):
                 newargs[arg] = Binary(val)
             else:
                 newargs[arg] = val
@@ -126,7 +126,7 @@ def unfixpickle(x):
     # if not a mapping, then a sequence
     newargs = []
     for arg in x:
-        if isinstance(arg, type(array.array("B"))):
+        if isinstance(arg, array.array):
             newargs.append(Binary(arg))
         else:
             newargs.append(arg)
diff --git a/adodbapi/test/adodbapitest.py b/adodbapi/test/adodbapitest.py
index 4b7b352a14..d7a4f2c9bc 100644
--- a/adodbapi/test/adodbapitest.py
+++ b/adodbapi/test/adodbapitest.py
@@ -1025,7 +1025,7 @@ def testRollBack(self):
         self.conn.rollback()
         crsr.execute(selectSql)
         assert (
-            crsr.fetchone() == None
+            crsr.fetchone() is None
         ), "cursor.fetchone should return None if a query retrieves no rows"
         crsr.execute("SELECT fldData from xx_%s" % config.tmp)
         rs = crsr.fetchall()
@@ -1082,7 +1082,7 @@ def testAutoRollback(self):
             row = crsr.fetchone()
         except api.DatabaseError:
             row = None  # if the entire table disappeared the rollback was perfect and the test passed
-        assert row == None, (
+        assert row is None, (
             "cursor.fetchone should return None if a query retrieves no rows. Got %s"
             % repr(row)
         )
@@ -1257,7 +1257,7 @@ def testMultipleSetReturn(self):
         assert crsr.nextset() == True, "third set should be present"
         rowdesc = crsr.fetchall()
         self.assertEqual(rowdesc[0][0], 8)
-        assert crsr.nextset() == None, "No more return sets, should return None"
+        assert crsr.nextset() is None, "No more return sets, should return None"
 
         self.helpRollbackTblTemp()
 
@@ -1348,7 +1348,7 @@ def getAnotherConnection(self, addkeys=None):
 
     def testOkConnect(self):
         c = self.db(*config.connStrAccess[0], **config.connStrAccess[1])
-        assert c != None
+        assert c is not None
         c.close()
 
 
@@ -1384,7 +1384,7 @@ def getAnotherConnection(self, addkeys=None):
 
     def testOkConnect(self):
         c = self.db(*config.connStrMySql[0], **config.connStrMySql[1])
-        assert c != None
+        assert c is not None
 
     # def testStoredProcedure(self):
     #     crsr=self.conn.cursor()
@@ -1450,7 +1450,7 @@ def getAnotherConnection(self, addkeys=None):
 
     def testOkConnect(self):
         c = self.db(*config.connStrPostgres[0], **config.connStrPostgres[1])
-        assert c != None
+        assert c is not None
 
     # def testStoredProcedure(self):
     #     crsr=self.conn.cursor()
diff --git a/adodbapi/test/test_adodbapi_dbapi20.py b/adodbapi/test/test_adodbapi_dbapi20.py
index 31bbae4827..6115138336 100644
--- a/adodbapi/test/test_adodbapi_dbapi20.py
+++ b/adodbapi/test/test_adodbapi_dbapi20.py
@@ -184,7 +184,7 @@ def test_nextset(self):
             names = cur.fetchall()
             assert len(names) == len(self.samples)
             s = cur.nextset()
-            assert s == None, "No more return sets, should return None"
+            assert s is None, "No more return sets, should return None"
         finally:
             try:
                 self.help_nextset_tearDown(cur)
diff --git a/com/win32com/client/__init__.py b/com/win32com/client/__init__.py
index 91b4b303b5..2a6b7d1c9a 100644
--- a/com/win32com/client/__init__.py
+++ b/com/win32com/client/__init__.py
@@ -605,7 +605,7 @@ def _get_good_object_(self, obj, obUserName=None, resultCLSID=None):
 
 # XXX - These should be consolidated with dynamic.py versions.
 def _get_good_single_object_(obj, obUserName=None, resultCLSID=None):
-    if _PyIDispatchType == type(obj):
+    if isinstance(obj, _PyIDispatchType):
         return Dispatch(obj, obUserName, resultCLSID)
     return obj
 
diff --git a/com/win32com/client/build.py b/com/win32com/client/build.py
index ce4e2e4aeb..dc43aae0a9 100644
--- a/com/win32com/client/build.py
+++ b/com/win32com/client/build.py
@@ -89,7 +89,7 @@ def __init__(
         resultDoc=None,
         hidden=0,
     ):
-        if type(desc_or_id) == type(0):
+        if isinstance(desc_or_id, int):
             self.dispid = desc_or_id
             self.desc = None
         else:
@@ -546,7 +546,7 @@ def __init__(self, attr, doc):
 def _ResolveType(typerepr, itypeinfo):
     # Resolve VT_USERDEFINED (often aliases or typed IDispatches)
 
-    if type(typerepr) == tuple:
+    if isinstance(typerepr, tuple):
         indir_vt, subrepr = typerepr
         if indir_vt == pythoncom.VT_PTR:
             # If it is a VT_PTR to a VT_USERDEFINED that is an IDispatch/IUnknown,
@@ -556,7 +556,9 @@ def _ResolveType(typerepr, itypeinfo):
             # eg, (VT_PTR, (VT_USERDEFINED, somehandle)) needs to become VT_DISPATCH
             # only when "somehandle" is an object.
             # but (VT_PTR, (VT_USERDEFINED, otherhandle)) doesnt get the indirection dropped.
-            was_user = type(subrepr) == tuple and subrepr[0] == pythoncom.VT_USERDEFINED
+            was_user = (
+                isinstance(subrepr, tuple) and subrepr[0] == pythoncom.VT_USERDEFINED
+            )
             subrepr, sub_clsid, sub_doc = _ResolveType(subrepr, itypeinfo)
             if was_user and subrepr in [
                 pythoncom.VT_DISPATCH,
@@ -701,7 +703,7 @@ def MakeDefaultArgRepr(defArgVal):
             # VARIANT <-> SYSTEMTIME conversions always lose any sub-second
             # resolution, so just use a 'timetuple' here.
             return repr(tuple(val.utctimetuple()))
-        if type(val) is TimeType:
+        if isinstance(val, TimeType):
             # must be the 'old' pywintypes time object...
             year = val.year
             month = val.month
diff --git a/com/win32com/client/combrowse.py b/com/win32com/client/combrowse.py
index 10eeaedfdb..be2e7805e0 100644
--- a/com/win32com/client/combrowse.py
+++ b/com/win32com/client/combrowse.py
@@ -59,7 +59,7 @@ def CalculateIsExpandable(self):
 
 class HLICLSID(HLICOM):
     def __init__(self, myobject, name=None):
-        if type(myobject) == type(""):
+        if isinstance(myobject, str):
             myobject = pythoncom.MakeIID(myobject)
         if name is None:
             try:
@@ -457,7 +457,7 @@ def MakeReturnTypeName(self, typ):
         return typname
 
     def MakeReturnType(self, returnTypeDesc):
-        if type(returnTypeDesc) == type(()):
+        if isinstance(returnTypeDesc, tuple):
             first = returnTypeDesc[0]
             result = self.MakeReturnType(first)
             if first != pythoncom.VT_USERDEFINED:
diff --git a/com/win32com/client/genpy.py b/com/win32com/client/genpy.py
index 3eba075fa3..8cda87debd 100644
--- a/com/win32com/client/genpy.py
+++ b/com/win32com/client/genpy.py
@@ -161,9 +161,8 @@ def __init__(self, typeinfo, attr, doc=None, bForUser=1):
 
         ai = attr[14]
         self.attr = attr
-        if type(ai) == type(()) and type(ai[1]) == type(
-            0
-        ):  # XXX - This is a hack - why tuples?  Need to resolve?
+        # XXX - This is a hack - why tuples?  Need to resolve?
+        if isinstance(ai, tuple) and isinstance(ai[1], int):
             href = ai[1]
             alinfo = typeinfo.GetRefTypeInfo(href)
             self.aliasDoc = alinfo.GetDocumentation(-1)
@@ -184,7 +183,7 @@ def WriteAliasItem(self, aliasDict, stream):
             print(self.doc[0] + " = " + depName, file=stream)
         else:
             ai = self.attr[14]
-            if type(ai) == type(0):
+            if isinstance(ai, int):
                 try:
                     typeStr = mapVTToTypeString[ai]
                     print("# %s=%s" % (self.doc[0], typeStr), file=stream)
diff --git a/com/win32com/client/makepy.py b/com/win32com/client/makepy.py
index 041f18a457..e06e61eb8d 100644
--- a/com/win32com/client/makepy.py
+++ b/com/win32com/client/makepy.py
@@ -348,7 +348,7 @@ def GenerateChildFromTypeLibSpec(
         verboseLevel = (
             0  # By default, we use no gui, and no verbose level for the children.
         )
-    if type(typelibInfo) == type(()):
+    if isinstance(typelibInfo, tuple):
         typelibCLSID, lcid, major, minor = typelibInfo
         tlb = pythoncom.LoadRegTypeLib(typelibCLSID, major, minor, lcid)
     else:
diff --git a/com/win32com/client/util.py b/com/win32com/client/util.py
index c5762951de..1925843ab3 100644
--- a/com/win32com/client/util.py
+++ b/com/win32com/client/util.py
@@ -16,7 +16,7 @@ def WrapEnum(ob, resultCLSID=None):
     (which may be either a class instance, or a dynamic.Dispatch type object).
 
     """
-    if type(ob) != pythoncom.TypeIIDs[pythoncom.IID_IEnumVARIANT]:
+    if not isinstance(ob, pythoncom.TypeIIDs[pythoncom.IID_IEnumVARIANT]):
         ob = ob.QueryInterface(pythoncom.IID_IEnumVARIANT)
     return EnumVARIANT(ob, resultCLSID)
 
@@ -44,7 +44,7 @@ def __call__(self, index):
         return self.__GetIndex(index)
 
     def __GetIndex(self, index):
-        if type(index) != type(0):
+        if not isinstance(index, int):
             raise TypeError("Only integer indexes are supported for enumerators")
         # NOTE
         # In this context, self.index is users purely as a flag to say
diff --git a/com/win32com/server/policy.py b/com/win32com/server/policy.py
index 8105e180a2..4184b0f8c8 100644
--- a/com/win32com/server/policy.py
+++ b/com/win32com/server/policy.py
@@ -259,7 +259,7 @@ def _wrap_(self, object):
             self._com_interfaces_ = []
             # Allow interfaces to be specified by name.
             for i in ob._com_interfaces_:
-                if type(i) != pywintypes.IIDType:
+                if not isinstance(i, pywintypes.IIDType):
                     # Prolly a string!
                     if i[0] != "{":
                         i = pythoncom.InterfaceNames[i]
@@ -295,7 +295,7 @@ def _Invoke_(self, dispid, lcid, wFlags, args):
         This calls the _invoke_ helper.
         """
         # Translate a possible string dispid to real dispid.
-        if type(dispid) == type(""):
+        if isinstance(dispid, str):
             try:
                 dispid = self._name_to_dispid_[dispid.lower()]
             except KeyError:
@@ -347,7 +347,7 @@ def _InvokeEx_(self, dispid, lcid, wFlags, args, kwargs, serviceProvider):
         This calls the _invokeex_ helper.
         """
         # Translate a possible string dispid to real dispid.
-        if type(dispid) == type(""):
+        if isinstance(dispid, str):
             try:
                 dispid = self._name_to_dispid_[dispid.lower()]
             except KeyError:
@@ -507,7 +507,7 @@ def _wrap_(self, ob):
             interfaces = [
                 i
                 for i in getattr(ob, "_com_interfaces_", [])
-                if type(i) != pywintypes.IIDType and not i.startswith("{")
+                if not isinstance(i, pywintypes.IIDType) and not i.startswith("{")
             ]
             universal_data = universal.RegisterInterfaces(
                 tlb_guid, tlb_lcid, tlb_major, tlb_minor, interfaces
@@ -652,7 +652,7 @@ def _invokeex_(self, dispid, lcid, wFlags, args, kwArgs, serviceProvider):
             except KeyError:
                 raise COMException(scode=winerror.DISP_E_MEMBERNOTFOUND)  # not found
             retob = getattr(self._obj_, name)
-            if type(retob) == types.MethodType:  # a method as a property - call it.
+            if isinstance(retob, types.MethodType):  # a method as a property - call it.
                 retob = retob(*args)
             return retob
 
@@ -663,11 +663,10 @@ def _invokeex_(self, dispid, lcid, wFlags, args, kwArgs, serviceProvider):
                 raise COMException(scode=winerror.DISP_E_MEMBERNOTFOUND)  # read-only
             # If we have a method of that name (ie, a property get function), and
             # we have an equiv. property set function, use that instead.
-            if (
-                type(getattr(self._obj_, name, None)) == types.MethodType
-                and type(getattr(self._obj_, "Set" + name, None)) == types.MethodType
+            fn = getattr(self._obj_, "Set" + name, None)
+            if isinstance(fn, types.MethodType) and isinstance(
+                getattr(self._obj_, name, None), types.MethodType
             ):
-                fn = getattr(self._obj_, "Set" + name)
                 fn(*args)
             else:
                 # just set the attribute
@@ -691,12 +690,11 @@ class EventHandlerPolicy(DesignatedWrapPolicy):
     def _transform_args_(self, args, kwArgs, dispid, lcid, wFlags, serviceProvider):
         ret = []
         for arg in args:
-            arg_type = type(arg)
-            if arg_type == IDispatchType:
+            if isinstance(arg, IDispatchType):
                 import win32com.client
 
                 arg = win32com.client.Dispatch(arg)
-            elif arg_type == IUnknownType:
+            elif isinstance(arg, IUnknownType):
                 try:
                     import win32com.client
 
diff --git a/com/win32com/servers/PythonTools.py b/com/win32com/servers/PythonTools.py
index 7f8f4d7609..1a84a7ccdf 100644
--- a/com/win32com/servers/PythonTools.py
+++ b/com/win32com/servers/PythonTools.py
@@ -14,7 +14,7 @@ def reload(self, module):
         return "no reload performed."
 
     def adddir(self, dir):
-        if type(dir) == type(""):
+        if isinstance(dir, str):
             sys.path.append(dir)
         return str(sys.path)
 
diff --git a/com/win32com/servers/dictionary.py b/com/win32com/servers/dictionary.py
index 28596b81a1..c8ec986377 100644
--- a/com/win32com/servers/dictionary.py
+++ b/com/win32com/servers/dictionary.py
@@ -75,7 +75,7 @@ def _invokeex_(self, dispid, lcid, wFlags, args, kwargs, serviceProvider):
                 )
 
             key = args[0]
-            if type(key) not in [str, str]:
+            if not isinstance(key, str):
                 ### the nArgErr thing should be 0-based, not reversed... sigh
                 raise COMException(
                     desc="Key must be a string", scode=winerror.DISP_E_TYPEMISMATCH
diff --git a/com/win32com/servers/interp.py b/com/win32com/servers/interp.py
index b15cede763..9636837b85 100644
--- a/com/win32com/servers/interp.py
+++ b/com/win32com/servers/interp.py
@@ -32,14 +32,14 @@ def __init__(self):
 
     def Eval(self, exp):
         """Evaluate an expression."""
-        if type(exp) != str:
+        if not isinstance(exp, str):
             raise Exception(desc="Must be a string", scode=winerror.DISP_E_TYPEMISMATCH)
 
         return eval(str(exp), self.dict)
 
     def Exec(self, exp):
         """Execute a statement."""
-        if type(exp) != str:
+        if not isinstance(exp, str):
             raise Exception(desc="Must be a string", scode=winerror.DISP_E_TYPEMISMATCH)
         exec(str(exp), self.dict)
 
diff --git a/com/win32com/test/GenTestScripts.py b/com/win32com/test/GenTestScripts.py
index 73bb26411c..4e5cf4a492 100644
--- a/com/win32com/test/GenTestScripts.py
+++ b/com/win32com/test/GenTestScripts.py
@@ -68,13 +68,13 @@ def CleanAll():
             name = args[0] + ".py"
             os.unlink(os.path.join(genPath, name))
         except os.error as details:
-            if type(details) == type(()) and details[0] != 2:
+            if isinstance(details, tuple) and details[0] != 2:
                 print("Could not deleted generated", name, details)
         try:
             name = args[0] + ".pyc"
             os.unlink(os.path.join(genPath, name))
         except os.error as details:
-            if type(details) == type(()) and details[0] != 2:
+            if isinstance(details, tuple) and details[0] != 2:
                 print("Could not deleted generated", name, details)
         try:
             os.unlink(os.path.join(genPath, "__init__.py"))
diff --git a/com/win32com/test/testArrays.py b/com/win32com/test/testArrays.py
index f395a4131a..aa4ad16af4 100644
--- a/com/win32com/test/testArrays.py
+++ b/com/win32com/test/testArrays.py
@@ -41,7 +41,7 @@
 
 
 def _normalize_array(a):
-    if type(a) != type(()):
+    if not isinstance(a, tuple):
         return a
     ret = []
     for i in a:
diff --git a/com/win32com/test/testDynamic.py b/com/win32com/test/testDynamic.py
index 2fd9197249..8dd1d82a67 100644
--- a/com/win32com/test/testDynamic.py
+++ b/com/win32com/test/testDynamic.py
@@ -18,7 +18,7 @@ def _dynamic_(self, name, lcid, wFlags, args):
             try:
                 # to avoid problems with byref param handling, tuple results are converted to lists.
                 ret = self.__dict__[name]
-                if type(ret) == type(()):
+                if isinstance(ret, tuple):
                     ret = list(ret)
                 return ret
             except KeyError:  # Probably a method request.
diff --git a/com/win32com/test/testIterators.py b/com/win32com/test/testIterators.py
index b75a78dfcd..8eba364a70 100644
--- a/com/win32com/test/testIterators.py
+++ b/com/win32com/test/testIterators.py
@@ -128,7 +128,7 @@ def suite():
     suite = unittest.TestSuite()
     for item in list(globals().values()):
         if (
-            type(item) == type(unittest.TestCase)
+            isinstance(item, type)
             and issubclass(item, unittest.TestCase)
             and item != _BaseTestCase
         ):
diff --git a/com/win32com/test/testMSOfficeEvents.py b/com/win32com/test/testMSOfficeEvents.py
index c173c3ef1d..e677afc67f 100644
--- a/com/win32com/test/testMSOfficeEvents.py
+++ b/com/win32com/test/testMSOfficeEvents.py
@@ -14,14 +14,16 @@
 def TestExcel():
     class ExcelEvents:
         def OnNewWorkbook(self, wb):
-            if type(wb) != types.InstanceType:
+            if not isinstance(wb, types.InstanceType):
                 raise RuntimeError(
                     "The transformer doesnt appear to have translated this for us!"
                 )
             self.seen_events["OnNewWorkbook"] = None
 
         def OnWindowActivate(self, wb, wn):
-            if type(wb) != types.InstanceType or type(wn) != types.InstanceType:
+            if not isinstance(wb, types.InstanceType) or not isinstance(
+                wn, types.InstanceType
+            ):
                 raise RuntimeError(
                     "The transformer doesnt appear to have translated this for us!"
                 )
diff --git a/com/win32com/test/testPersist.py b/com/win32com/test/testPersist.py
index 1371498cc8..6dde9c168d 100644
--- a/com/win32com/test/testPersist.py
+++ b/com/win32com/test/testPersist.py
@@ -118,7 +118,7 @@ def SetIStorage(self, IStorage):
 
     def SaveObject(self):
         print("SaveObject")
-        if self.IPersistStorage != None and self.IStorage != None:
+        if self.IPersistStorage is not None and self.IStorage is not None:
             self.IPersistStorage.Save(self.IStorage, 1)
             self.IStorage.Commit(0)
         return S_OK
diff --git a/com/win32com/test/testPyComTest.py b/com/win32com/test/testPyComTest.py
index aec0a6f584..e7b065b239 100644
--- a/com/win32com/test/testPyComTest.py
+++ b/com/win32com/test/testPyComTest.py
@@ -117,7 +117,7 @@ def OnFireWithNamedParams(self, no, a_bool, out1, out2):
             assert no + 1 == out1, "expecting 'out1' param to be ID+1"
             assert no + 2 == out2, "expecting 'out2' param to be ID+2"
         # The middle must be a boolean.
-        assert a_bool is Missing or type(a_bool) == bool, "middle param not a bool"
+        assert a_bool is Missing or isinstance(a_bool, bool), "middle param not a bool"
         return out1 + 2, out2 + 2
 
     def _DumpFireds(self):
@@ -149,7 +149,7 @@ def OnFireWithNamedParams(self, no, a_bool, out1, out2):
             assert no + 1 == out1, "expecting 'out1' param to be ID+1"
             assert no + 2 == out2, "expecting 'out2' param to be ID+2"
         # The middle must be a boolean.
-        assert a_bool is Missing or type(a_bool) == bool, "middle param not a bool"
+        assert a_bool is Missing or isinstance(a_bool, bool), "middle param not a bool"
         return out1 + 2, out2 + 2
 
     def _DumpFireds(self):
@@ -577,7 +577,7 @@ def _TestPyVariant(o, is_generated, val, checker=None):
     assert vt == val.varianttype, (vt, val.varianttype)
     # Handle our safe-array test - if the passed value is a list of variants,
     # compare against the actual values.
-    if type(val.value) in (tuple, list):
+    if isinstance(val.value, (tuple, list)):
         check = [v.value if isinstance(v, VARIANT) else v for v in val.value]
         # pythoncom always returns arrays as tuples.
         got = list(got)
diff --git a/com/win32com/test/testvb.py b/com/win32com/test/testvb.py
index 5a3d2f73d4..369bdca859 100644
--- a/com/win32com/test/testvb.py
+++ b/com/win32com/test/testvb.py
@@ -178,7 +178,7 @@ def _DoTestCollection(vbtest, col_name, expected):
     # It sucks that some objects allow "Count()", but others "Count"
     def _getcount(ob):
         r = getattr(ob, "Count")
-        if type(r) != type(0):
+        if isinstance(r, Callable):
             return r()
         return r
 
@@ -424,7 +424,7 @@ def TestStructs(vbtest):
 
     # Now do some object equality tests.
     assert s == s
-    assert s != None
+    assert s is not None
     if sys.version_info > (3, 0):
         try:
             s < None
@@ -525,9 +525,9 @@ def TestObjectSemantics(ob):
     assert ob._oleobj_ == ob._oleobj_.QueryInterface(pythoncom.IID_IUnknown)
     assert not ob._oleobj_ != ob._oleobj_.QueryInterface(pythoncom.IID_IUnknown)
 
-    assert ob._oleobj_ != None
+    assert ob._oleobj_ is not None
     assert None != ob._oleobj_
-    assert ob != None
+    assert ob is not None
     assert None != ob
     if sys.version_info > (3, 0):
         try:
diff --git a/com/win32com/universal.py b/com/win32com/universal.py
index 7c2944ed10..f7d86e4dde 100644
--- a/com/win32com/universal.py
+++ b/com/win32com/universal.py
@@ -206,7 +206,7 @@ def dispatch(
         retVal = ob._InvokeEx_(meth.dispid, 0, meth.invkind, args, None, None)
         # None is an allowed return value stating that
         # the code doesn't want to touch any output arguments.
-        if type(retVal) == tuple:  # Like pythoncom, we special case a tuple.
+        if isinstance(retVal, tuple):  # Like pythoncom, we special case a tuple.
             # However, if they want to return a specific HRESULT,
             # then they have to return all of the out arguments
             # AND the HRESULT.
diff --git a/com/win32comext/adsi/__init__.py b/com/win32comext/adsi/__init__.py
index ab95196f68..69b4c53c33 100644
--- a/com/win32comext/adsi/__init__.py
+++ b/com/win32comext/adsi/__init__.py
@@ -1,7 +1,7 @@
 import win32com
 import win32com.client
 
-if type(__path__) == type(""):
+if isinstance(__path__, str):
     # For freeze to work!
     import sys
 
@@ -62,7 +62,7 @@ def __call__(self, index):
         return self.__GetIndex(index)
 
     def __GetIndex(self, index):
-        if type(index) != type(0):
+        if not isinstance(index, int):
             raise TypeError("Only integer indexes are supported for enumerators")
         if index != self.index + 1:
             # Index requested out of sequence.
diff --git a/com/win32comext/adsi/demos/scp.py b/com/win32comext/adsi/demos/scp.py
index d1a4ca05ec..cc96e5a878 100644
--- a/com/win32comext/adsi/demos/scp.py
+++ b/com/win32comext/adsi/demos/scp.py
@@ -219,7 +219,7 @@ def SpnRegister(
     spns,  # List of SPNs to register
     operation,  # Add, replace, or delete SPNs
 ):
-    assert type(spns) not in [str, str] and hasattr(spns, "__iter__"), (
+    assert not isinstance(spns, str) and hasattr(spns, "__iter__"), (
         "spns must be a sequence of strings (got %r)" % spns
     )
     # Bind to a domain controller.
diff --git a/com/win32comext/adsi/demos/test.py b/com/win32comext/adsi/demos/test.py
index a1dba34dc5..d5b8fde98e 100644
--- a/com/win32comext/adsi/demos/test.py
+++ b/com/win32comext/adsi/demos/test.py
@@ -231,7 +231,7 @@ def main():
 
     tests = []
     for ob in globals().values():
-        if type(ob) == type(main) and ob.__doc__:
+        if isinstance(ob, Callable) and ob.__doc__:
             tests.append(ob)
     opts, args = getopt.getopt(sys.argv[1:], "s:hv")
     for opt, val in opts:
diff --git a/com/win32comext/axdebug/codecontainer.py b/com/win32comext/axdebug/codecontainer.py
index c390955681..44c5f0e797 100644
--- a/com/win32comext/axdebug/codecontainer.py
+++ b/com/win32comext/axdebug/codecontainer.py
@@ -261,7 +261,7 @@ def GetName(self, dnt):
     attrs = sc.GetSyntaxColorAttributes()
     attrlen = 0
     for attr in attrs:
-        if type(attr) == type(()):
+        if isinstance(attr, tuple):
             attrlen = attrlen + attr[1]
         else:
             attrlen = attrlen + 1
diff --git a/com/win32comext/axscript/client/error.py b/com/win32comext/axscript/client/error.py
index 1dfa54fa2f..8ab7ec787a 100644
--- a/com/win32comext/axscript/client/error.py
+++ b/com/win32comext/axscript/client/error.py
@@ -202,8 +202,8 @@ def _BuildFromOther(self, site, exc_type, value, tb):
         # don't have a decode method...
         if sys.version_info < (3,):
             for i in range(len(bits)):
-                if type(bits[i]) is str:
-                    # assert type(bits[i]) is str, type(bits[i])
+                if isinstance(bits[i], str):
+                    # assert isinstance(bits[i], str), type(bits[i])
                     bits[i] = bits[i].decode("utf8")
 
         self.description = ExpandTabs("".join(bits))
diff --git a/com/win32comext/axscript/client/framework.py b/com/win32comext/axscript/client/framework.py
index d7b56a7cbe..2274f4e089 100644
--- a/com/win32comext/axscript/client/framework.py
+++ b/com/win32comext/axscript/client/framework.py
@@ -356,7 +356,7 @@ def Register(self):
         # 			id = self.parentItem.dispatch.GetIDsOfNames(self.name)
         # 			print "DispID of me is", id
         # 			result = self.parentItem.dispatch.Invoke(id, 0, pythoncom.DISPATCH_PROPERTYGET,1)
-        # 			if type(result)==pythoncom.TypeIIDs[pythoncom.IID_IDispatch]:
+        # 			if isinstance(result, pythoncom.TypeIIDs[pythoncom.IID_IDispatch]):
         # 				self.dispatch = result
         # 			else:
         # 				print "*** No dispatch"
@@ -509,7 +509,9 @@ def FindBuildSubItemEvents(self):
                         # as no event handler for "top" would work.
                         # I think we simply need to connect to a *single* event handler.
                         # As use in IE is deprecated, I am not solving this now.
-                        if type(result) == pythoncom.TypeIIDs[pythoncom.IID_IDispatch]:
+                        if isinstance(
+                            result, pythoncom.TypeIIDs[pythoncom.IID_IDispatch]
+                        ):
                             name = names[0]
                             subObj = self.GetCreateSubItem(
                                 self, name, result, axscript.SCRIPTITEM_ISVISIBLE
diff --git a/com/win32comext/axscript/client/pyscript.py b/com/win32comext/axscript/client/pyscript.py
index d2b21b58e1..5cbcffe3af 100644
--- a/com/win32comext/axscript/client/pyscript.py
+++ b/com/win32comext/axscript/client/pyscript.py
@@ -333,7 +333,7 @@ def DoProcessScriptItemEvent(self, item, event, lcid, wFlags, args):
         codeBlock = function = None
         try:
             function = item.scriptlets[funcName]
-            if type(function) == type(self):  # ie, is a CodeBlock instance
+            if isinstance(function, PyScript):  # ie, is a CodeBlock instance
                 codeBlock = function
                 function = None
         except KeyError:
diff --git a/com/win32comext/axscript/client/scriptdispatch.py b/com/win32comext/axscript/client/scriptdispatch.py
index 525326e7d6..c1989dc286 100644
--- a/com/win32comext/axscript/client/scriptdispatch.py
+++ b/com/win32comext/axscript/client/scriptdispatch.py
@@ -21,7 +21,7 @@
 
 
 def _is_callable(obj):
-    return type(obj) in [types.FunctionType, types.MethodType]
+    return isinstance(obj, (types.FunctionType, types.MethodType))
     # ignore hasattr(obj, "__call__") as this means all COM objects!
 
 
@@ -44,7 +44,7 @@ def _dynamic_(self, name, lcid, wFlags, args):
                     raise AttributeError(name)  # Not a function.
                 realArgs = []
                 for arg in args:
-                    if type(arg) == PyIDispatchType:
+                    if isinstance(arg, PyIDispatchType):
                         realArgs.append(Dispatch(arg))
                     else:
                         realArgs.append(arg)
diff --git a/com/win32comext/axscript/server/axsite.py b/com/win32comext/axscript/server/axsite.py
index d07ed120d0..8f0dd33b17 100644
--- a/com/win32comext/axscript/server/axsite.py
+++ b/com/win32comext/axscript/server/axsite.py
@@ -8,7 +8,7 @@
 class AXEngine:
     def __init__(self, site, engine):
         self.eScript = self.eParse = self.eSafety = None
-        if type(engine) == type(""):
+        if isinstance(engine, str):
             engine = pythoncom.CoCreateInstance(
                 engine, None, pythoncom.CLSCTX_SERVER, pythoncom.IID_IUnknown
             )
@@ -87,7 +87,7 @@ def AddEngine(self, engine):
         """Adds a new engine to the site.
         engine can be a string, or a fully wrapped engine object.
         """
-        if type(engine) == type(""):
+        if isinstance(engine, str):
             newEngine = AXEngine(util.wrap(self), engine)
         else:
             newEngine = engine
diff --git a/com/win32comext/directsound/test/ds_test.py b/com/win32comext/directsound/test/ds_test.py
index 84259ee2b0..1a4d5f94e1 100644
--- a/com/win32comext/directsound/test/ds_test.py
+++ b/com/win32comext/directsound/test/ds_test.py
@@ -77,7 +77,7 @@ class WAVEFORMATTest(unittest.TestCase):
     def test_1_Type(self):
         "WAVEFORMATEX type"
         w = pywintypes.WAVEFORMATEX()
-        self.assertTrue(type(w) == pywintypes.WAVEFORMATEXType)
+        self.assertTrue(isinstance(w, pywintypes.WAVEFORMATEXType))
 
     def test_2_Attr(self):
         "WAVEFORMATEX attribute access"
@@ -102,7 +102,7 @@ class DSCAPSTest(unittest.TestCase):
     def test_1_Type(self):
         "DSCAPS type"
         c = ds.DSCAPS()
-        self.assertTrue(type(c) == ds.DSCAPSType)
+        self.assertTrue(isinstance(c, ds.DSCAPSType))
 
     def test_2_Attr(self):
         "DSCAPS attribute access"
@@ -156,7 +156,7 @@ class DSBCAPSTest(unittest.TestCase):
     def test_1_Type(self):
         "DSBCAPS type"
         c = ds.DSBCAPS()
-        self.assertTrue(type(c) == ds.DSBCAPSType)
+        self.assertTrue(isinstance(c, ds.DSBCAPSType))
 
     def test_2_Attr(self):
         "DSBCAPS attribute access"
@@ -176,7 +176,7 @@ class DSCCAPSTest(unittest.TestCase):
     def test_1_Type(self):
         "DSCCAPS type"
         c = ds.DSCCAPS()
-        self.assertTrue(type(c) == ds.DSCCAPSType)
+        self.assertTrue(isinstance(c, ds.DSCCAPSType))
 
     def test_2_Attr(self):
         "DSCCAPS attribute access"
@@ -194,7 +194,7 @@ class DSCBCAPSTest(unittest.TestCase):
     def test_1_Type(self):
         "DSCBCAPS type"
         c = ds.DSCBCAPS()
-        self.assertTrue(type(c) == ds.DSCBCAPSType)
+        self.assertTrue(isinstance(c, ds.DSCBCAPSType))
 
     def test_2_Attr(self):
         "DSCBCAPS attribute access"
@@ -210,7 +210,7 @@ class DSBUFFERDESCTest(unittest.TestCase):
     def test_1_Type(self):
         "DSBUFFERDESC type"
         c = ds.DSBUFFERDESC()
-        self.assertTrue(type(c) == ds.DSBUFFERDESCType)
+        self.assertTrue(isinstance(c, ds.DSBUFFERDESCType))
 
     def test_2_Attr(self):
         "DSBUFFERDESC attribute access"
@@ -247,7 +247,7 @@ class DSCBUFFERDESCTest(unittest.TestCase):
     def test_1_Type(self):
         "DSCBUFFERDESC type"
         c = ds.DSCBUFFERDESC()
-        self.assertTrue(type(c) == ds.DSCBUFFERDESCType)
+        self.assertTrue(isinstance(c, ds.DSCBUFFERDESCType))
 
     def test_2_Attr(self):
         "DSCBUFFERDESC attribute access"
diff --git a/com/win32comext/ifilter/demo/filterDemo.py b/com/win32comext/ifilter/demo/filterDemo.py
index 30742d8a3b..1eb7a01c0e 100644
--- a/com/win32comext/ifilter/demo/filterDemo.py
+++ b/com/win32comext/ifilter/demo/filterDemo.py
@@ -291,7 +291,7 @@ def _usage():
                     reduce(operator.add, [len(p) for p in propValue]),
                 )
             )
-        elif type(propValue) == type([]):
+        elif isinstance(propValue, list):
             print()
             for pv in propValue:
                 print(pv)
diff --git a/com/win32comext/mapi/__init__.py b/com/win32comext/mapi/__init__.py
index 3933e21288..d15a79e1f9 100644
--- a/com/win32comext/mapi/__init__.py
+++ b/com/win32comext/mapi/__init__.py
@@ -1,4 +1,4 @@
-if type(__path__) == type(""):
+if isinstance(__path__, str):
     # For freeze to work!
     import sys
 
diff --git a/com/win32comext/mapi/mapiutil.py b/com/win32comext/mapi/mapiutil.py
index c9519414aa..8a5ffb6323 100644
--- a/com/win32comext/mapi/mapiutil.py
+++ b/com/win32comext/mapi/mapiutil.py
@@ -103,13 +103,13 @@ def GetProperties(obj, propList):
     If the property fetch fails, the result is None.
     """
     bRetList = 1
-    if type(propList) not in [TupleType, ListType]:
+    if not isinstance(propList, (TupleType, ListType)):
         bRetList = 0
         propList = (propList,)
     realPropList = []
     rc = []
     for prop in propList:
-        if type(prop) != IntType:  # Integer
+        if not isinstance(prop, IntType):  # Integer
             props = ((mapi.PS_PUBLIC_STRINGS, prop),)
             propIds = obj.GetIDsFromNames(props, 0)
             prop = mapitags.PROP_TAG(
@@ -134,7 +134,7 @@ def GetAllProperties(obj, make_tag_names=True):
     for tag, val in data:
         if make_tag_names:
             hr, tags, array = obj.GetNamesFromIDs((tag,))
-            if type(array[0][1]) == type(""):
+            if isinstance(array[0][1], str):
                 name = array[0][1]
             else:
                 name = GetPropTagName(tag)
@@ -157,7 +157,7 @@ def GetAllProperties(obj, make_tag_names=True):
 
 
 def SetPropertyValue(obj, prop, val):
-    if type(prop) != IntType:
+    if not isinstance(prop, IntType):
         props = ((mapi.PS_PUBLIC_STRINGS, prop),)
         propIds = obj.GetIDsFromNames(props, mapi.MAPI_CREATE)
         if val == (1 == 1) or val == (1 == 0):
@@ -190,7 +190,7 @@ def SetProperties(msg, propDict):
     newProps = []
     # First pass over the properties we should get IDs for.
     for key, val in propDict.items():
-        if type(key) == str:
+        if isinstance(key, str):
             newProps.append((mapi.PS_PUBLIC_STRINGS, key))
     # Query for the new IDs
     if newProps:
@@ -198,18 +198,17 @@ def SetProperties(msg, propDict):
     newIdNo = 0
     newProps = []
     for key, val in propDict.items():
-        if type(key) == str:
-            type_val = type(val)
-            if type_val == str:
+        if isinstance(key, str):
+            if isinstance(val, str):
                 tagType = mapitags.PT_UNICODE
-            elif type_val == IntType:
+            elif isinstance(val, int):
                 tagType = mapitags.PT_I4
-            elif type_val == TimeType:
+            elif isinstance(val, TimeType):
                 tagType = mapitags.PT_SYSTIME
             else:
                 raise ValueError(
                     "The type of object %s(%s) can not be written"
-                    % (repr(val), type_val)
+                    % (repr(val), type(val))
                 )
             key = mapitags.PROP_TAG(tagType, mapitags.PROP_ID(newIds[newIdNo]))
             newIdNo = newIdNo + 1
diff --git a/com/win32comext/shell/demos/servers/empty_volume_cache.py b/com/win32comext/shell/demos/servers/empty_volume_cache.py
index a257ac1756..a10d150e9f 100644
--- a/com/win32comext/shell/demos/servers/empty_volume_cache.py
+++ b/com/win32comext/shell/demos/servers/empty_volume_cache.py
@@ -93,7 +93,7 @@ def _WalkCallback(self, arg, directory, files):
         for file in files:
             fqn = os.path.join(directory, file).lower()
             if file.endswith(".pyc") or file.endswith(".pyo"):
-                # See below - total_list == None means delete files,
+                # See below - total_list is None means delete files,
                 # otherwise it is a list where the result is stored. Its a
                 # list simply due to the way os.walk works - only [0] is
                 # referenced
diff --git a/com/win32comext/shell/demos/servers/shell_view.py b/com/win32comext/shell/demos/servers/shell_view.py
index 7d8bc51bae..29b66ac573 100644
--- a/com/win32comext/shell/demos/servers/shell_view.py
+++ b/com/win32comext/shell/demos/servers/shell_view.py
@@ -853,7 +853,7 @@ def CreateViewWindow(self, prev, settings, browser, rect):
 
         self._SetupLexer()
         self._SendSci(scintillacon.SCI_ADDTEXT, len(file_data), file_data)
-        if self.lineno != None:
+        if self.lineno is not None:
             self._SendSci(scintillacon.SCI_GOTOLINE, self.lineno)
         print("Scintilla's hwnd is", self.hwnd)
 
diff --git a/win32/Demos/FileSecurityTest.py b/win32/Demos/FileSecurityTest.py
index 90c454833f..3b8940b644 100644
--- a/win32/Demos/FileSecurityTest.py
+++ b/win32/Demos/FileSecurityTest.py
@@ -45,7 +45,7 @@
 # get ACEs
 sd = win32security.GetFileSecurity(name, win32security.DACL_SECURITY_INFORMATION)
 dacl = sd.GetSecurityDescriptorDacl()
-if dacl == None:
+if dacl is None:
     print("No Discretionary ACL")
 else:
     for ace_no in range(0, dacl.GetAceCount()):
diff --git a/win32/Demos/rastest.py b/win32/Demos/rastest.py
index 669a2a800b..e737acd9de 100644
--- a/win32/Demos/rastest.py
+++ b/win32/Demos/rastest.py
@@ -156,7 +156,7 @@ def main():
             ShowConnections()
         if opt == "-c":
             hras, rc = Connect(val, bCallback)
-            if hras != None:
+            if hras is not None:
                 print("hras: 0x%8lx, rc: 0x%04x" % (hras, rc))
         if opt == "-d":
             Disconnect(val)
diff --git a/win32/Demos/security/explicit_entries.py b/win32/Demos/security/explicit_entries.py
index b04f45173f..be37ee047c 100644
--- a/win32/Demos/security/explicit_entries.py
+++ b/win32/Demos/security/explicit_entries.py
@@ -56,10 +56,10 @@
 sd = win32security.GetFileSecurity(fname, all_security_info)
 
 old_sacl = sd.GetSecurityDescriptorSacl()
-if old_sacl == None:
+if old_sacl is None:
     old_sacl = win32security.ACL()
 old_dacl = sd.GetSecurityDescriptorDacl()
-if old_dacl == None:
+if old_dacl is None:
     old_dacl = win32security.ACL()
 
 my_sid = win32security.GetTokenInformation(th, ntsecuritycon.TokenUser)[0]
diff --git a/win32/Demos/win32clipboardDemo.py b/win32/Demos/win32clipboardDemo.py
index e3a3fab03a..c65f546643 100644
--- a/win32/Demos/win32clipboardDemo.py
+++ b/win32/Demos/win32clipboardDemo.py
@@ -44,7 +44,9 @@ def TestText():
         # CF_UNICODE text always gives unicode objects back.
         got = GetClipboardData(win32con.CF_UNICODETEXT)
         assert got == text, "Didnt get the correct result back - '%r'." % (got,)
-        assert type(got) == str, "Didnt get the correct result back - '%r'." % (got,)
+        assert isinstance(got, str), "Didnt get the correct result back - '%r'." % (
+            got,
+        )
 
         # CF_OEMTEXT is a bytes-based format.
         got = GetClipboardData(win32con.CF_OEMTEXT)
@@ -59,7 +61,9 @@ def TestText():
         # Get it in Unicode.
         got = GetClipboardData(win32con.CF_UNICODETEXT)
         assert got == text, "Didnt get the correct result back - '%r'." % (got,)
-        assert type(got) == str, "Didnt get the correct result back - '%r'." % (got,)
+        assert isinstance(got, str), "Didnt get the correct result back - '%r'." % (
+            got,
+        )
 
         # Close and open the clipboard to ensure auto-conversions take place.
     finally:
@@ -72,7 +76,9 @@ def TestText():
         assert got == text_bytes, "Didnt get the correct result back - '%r'." % (got,)
         # Make sure we get back the correct types.
         got = GetClipboardData(win32con.CF_UNICODETEXT)
-        assert type(got) == str, "Didnt get the correct result back - '%r'." % (got,)
+        assert isinstance(got, str), "Didnt get the correct result back - '%r'." % (
+            got,
+        )
         got = GetClipboardData(win32con.CF_OEMTEXT)
         assert got == text_bytes, "Didnt get the correct result back - '%r'." % (got,)
         print("Clipboard text tests worked correctly")
diff --git a/win32/Demos/win32comport_demo.py b/win32/Demos/win32comport_demo.py
index c0be23917e..9266292b25 100644
--- a/win32/Demos/win32comport_demo.py
+++ b/win32/Demos/win32comport_demo.py
@@ -49,7 +49,7 @@ def FindModem():
 # A basic synchronous COM port file-like object
 class SerialTTY:
     def __init__(self, port):
-        if type(port) == type(0):
+        if isinstance(port, int):
             port = "COM%d" % (port,)
         self.handle = CreateFile(
             port,
diff --git a/win32/Demos/win32netdemo.py b/win32/Demos/win32netdemo.py
index 36c495424b..e9bca62106 100644
--- a/win32/Demos/win32netdemo.py
+++ b/win32/Demos/win32netdemo.py
@@ -1,6 +1,7 @@
 import getopt
 import sys
 import traceback
+from collections.abc import Callable
 
 import win32api
 import win32net
@@ -229,7 +230,7 @@ def usage(tests):
 def main():
     tests = []
     for ob in list(globals().values()):
-        if type(ob) == type(main) and ob.__doc__:
+        if isinstance(ob, Callable) and ob.__doc__:
             tests.append(ob)
     opts, args = getopt.getopt(sys.argv[1:], "s:hvc")
     create_user = False
diff --git a/win32/Lib/regutil.py b/win32/Lib/regutil.py
index 1abdd551a9..db6d849af2 100644
--- a/win32/Lib/regutil.py
+++ b/win32/Lib/regutil.py
@@ -46,9 +46,9 @@ def SetRegistryDefaultValue(subKey, value, rootkey=None):
     """A helper to set the default value for a key in the registry"""
     if rootkey is None:
         rootkey = GetRootKey()
-    if type(value) == str:
+    if isinstance(value, str):
         typeId = win32con.REG_SZ
-    elif type(value) == int:
+    elif isinstance(value, int):
         typeId = win32con.REG_DWORD
     else:
         raise TypeError("Value must be string or integer - was passed " + repr(value))
diff --git a/win32/Lib/sspi.py b/win32/Lib/sspi.py
index c6f92ad381..855a4c35b8 100644
--- a/win32/Lib/sspi.py
+++ b/win32/Lib/sspi.py
@@ -209,9 +209,8 @@ def __init__(
 
     def authorize(self, sec_buffer_in):
         """Perform *one* step of the client authentication process. Pass None for the first round"""
-        if (
-            sec_buffer_in is not None
-            and type(sec_buffer_in) != win32security.PySecBufferDescType
+        if sec_buffer_in is not None and not isinstance(
+            sec_buffer_in, win32security.PySecBufferDescType
         ):
             # User passed us the raw data - wrap it into a SecBufferDesc
             sec_buffer_new = win32security.PySecBufferDescType()
@@ -287,9 +286,8 @@ def __init__(
 
     def authorize(self, sec_buffer_in):
         """Perform *one* step of the server authentication process."""
-        if (
-            sec_buffer_in is not None
-            and type(sec_buffer_in) != win32security.PySecBufferDescType
+        if sec_buffer_in is not None and not isinstance(
+            sec_buffer_in, win32security.PySecBufferDescType
         ):
             # User passed us the raw data - wrap it into a SecBufferDesc
             sec_buffer_new = win32security.PySecBufferDescType()
diff --git a/win32/Lib/win32rcparser.py b/win32/Lib/win32rcparser.py
index fdf7f57ccd..1d90bfd717 100644
--- a/win32/Lib/win32rcparser.py
+++ b/win32/Lib/win32rcparser.py
@@ -250,7 +250,7 @@ def load(self, rcstream):
         """
         self.open(rcstream)
         self.getToken()
-        while self.token != None:
+        while self.token is not None:
             self.parse()
             self.getToken()
 
@@ -412,7 +412,7 @@ def parse_dialog(self, name):
         self.getToken()  # number
         dlg.h = int(self.token)
         self.getToken()
-        while not (self.token == None or self.token == "" or self.token == "END"):
+        while not (self.token is None or self.token == "" or self.token == "END"):
             if self.token == "STYLE":
                 self.dialogStyle(dlg)
             elif self.token == "EXSTYLE":
@@ -444,7 +444,7 @@ def styles(self, defaults, defaultStyle):
         Not = False
         while (
             (i % 2 == 1 and ("|" == self.token or "NOT" == self.token)) or (i % 2 == 0)
-        ) and not self.token == None:
+        ) and not self.token is None:
             Not = False
             if "NOT" == self.token:
                 Not = True
diff --git a/win32/Lib/win32serviceutil.py b/win32/Lib/win32serviceutil.py
index fb1875302c..82e0a49431 100644
--- a/win32/Lib/win32serviceutil.py
+++ b/win32/Lib/win32serviceutil.py
@@ -375,7 +375,7 @@ def SetServiceCustomOption(serviceName, option, value):
         "System\\CurrentControlSet\\Services\\%s\\Parameters" % serviceName,
     )
     try:
-        if type(value) == type(0):
+        if isinstance(value, int):
             win32api.RegSetValueEx(key, option, 0, win32con.REG_DWORD, value)
         else:
             win32api.RegSetValueEx(key, option, 0, win32con.REG_SZ, value)
@@ -441,7 +441,7 @@ def ControlService(serviceName, code, machine=None):
 
 
 def __FindSvcDeps(findName):
-    if type(findName) is pywintypes.UnicodeType:
+    if isinstance(findName, pywintypes.UnicodeType):
         findName = str(findName)
     dict = {}
     k = win32api.RegOpenKey(
diff --git a/win32/Lib/win32timezone.py b/win32/Lib/win32timezone.py
index 569ea9b941..d0b9a08d1c 100644
--- a/win32/Lib/win32timezone.py
+++ b/win32/Lib/win32timezone.py
@@ -1014,7 +1014,7 @@ def bounds(self):
         )
 
     # some special values for the RangeMap
-    undefined_value = type(str("RangeValueUndefined"), (object,), {})()
+    undefined_value = type("RangeValueUndefined", (object,), {})()
 
     class Item(int):
         pass
diff --git a/win32/scripts/ce/pysynch.py b/win32/scripts/ce/pysynch.py
index 7a44e08222..c3054f0e2e 100644
--- a/win32/scripts/ce/pysynch.py
+++ b/win32/scripts/ce/pysynch.py
@@ -244,7 +244,7 @@ def DumpCommands():
     print("%-10s - %s" % ("Command", "Description"))
     print("%-10s - %s" % ("-------", "-----------"))
     for name, item in list(globals().items()):
-        if type(item) == type(DumpCommands):
+        if isinstance(item, Callable):
             doc = getattr(item, "__doc__", "")
             if doc:
                 lines = string.split(doc, "\n")
diff --git a/win32/scripts/rasutil.py b/win32/scripts/rasutil.py
index e5a8922d72..3c13d49682 100644
--- a/win32/scripts/rasutil.py
+++ b/win32/scripts/rasutil.py
@@ -49,7 +49,7 @@ def Connect(rasEntryName, numRetries=5):
 
 
 def Disconnect(handle):
-    if type(handle) == type(""):  # have they passed a connection name?
+    if isinstance(handle, str):  # have they passed a connection name?
         for info in win32ras.EnumConnections():
             if info[1].lower() == handle.lower():
                 handle = info[0]
diff --git a/win32/scripts/regsetup.py b/win32/scripts/regsetup.py
index d654b84183..f04dbda766 100644
--- a/win32/scripts/regsetup.py
+++ b/win32/scripts/regsetup.py
@@ -328,7 +328,7 @@ def FindRegisterApp(appName, knownFiles, searchPaths):
 
     import regutil
 
-    if type(knownFiles) == type(""):
+    if isinstance(knownFiles, str):
         knownFiles = [knownFiles]
     paths = []
     try:
diff --git a/win32/test/handles.py b/win32/test/handles.py
index ad607353e8..98b73625db 100644
--- a/win32/test/handles.py
+++ b/win32/test/handles.py
@@ -113,8 +113,8 @@ def testHandleCompareNone(self):
         self.assertNotEqual(h, None)
         self.assertNotEqual(None, h)
         # ensure we use both __eq__ and __ne__ ops
-        self.assertFalse(h == None)
-        self.assertTrue(h != None)
+        self.assertFalse(h is None)
+        self.assertTrue(h is not None)
 
     def testHandleCompareInt(self):
         h = pywintypes.HANDLE(1)
diff --git a/win32/test/test_pywintypes.py b/win32/test/test_pywintypes.py
index 44b5c960cb..1f9cd9e7df 100644
--- a/win32/test/test_pywintypes.py
+++ b/win32/test/test_pywintypes.py
@@ -93,9 +93,9 @@ def testGUID(self):
     def testGUIDRichCmp(self):
         s = "{00020400-0000-0000-C000-000000000046}"
         iid = pywintypes.IID(s)
-        self.assertFalse(s == None)
+        self.assertFalse(s is None)
         self.assertFalse(None == s)
-        self.assertTrue(s != None)
+        self.assertTrue(s is not None)
         self.assertTrue(None != s)
         if sys.version_info > (3, 0):
             self.assertRaises(TypeError, operator.gt, None, s)
diff --git a/win32/test/test_security.py b/win32/test/test_security.py
index 42a82a134d..dc80fb4295 100644
--- a/win32/test/test_security.py
+++ b/win32/test/test_security.py
@@ -39,9 +39,9 @@ def testNESID(self):
             self.assertTrue(self.pwr_sid != self.admin_sid)
 
     def testNEOther(self):
-        self.assertTrue(self.pwr_sid != None)
+        self.assertTrue(self.pwr_sid is not None)
         self.assertTrue(None != self.pwr_sid)
-        self.assertFalse(self.pwr_sid == None)
+        self.assertFalse(self.pwr_sid is None)
         self.assertFalse(None == self.pwr_sid)
         self.assertNotEqual(None, self.pwr_sid)
 
diff --git a/win32/test/test_win32api.py b/win32/test/test_win32api.py
index 416f310222..81b2fe5ef9 100644
--- a/win32/test/test_win32api.py
+++ b/win32/test/test_win32api.py
@@ -154,7 +154,7 @@ def testShortLongPathNames(self):
         self.assertEqual(long_name, win32api.GetLongPathNameW(short_name).lower())
         long_name = win32api.GetLongPathNameW(short_name).lower()
         self.assertTrue(
-            type(long_name) == str,
+            isinstance(long_name, str),
             "GetLongPathNameW returned type '%s'" % (type(long_name),),
         )
         self.assertTrue(
@@ -179,7 +179,7 @@ def testShortUnicodeNames(self):
         self.assertEqual(long_name, win32api.GetLongPathNameW(short_name).lower())
         long_name = win32api.GetLongPathNameW(short_name).lower()
         self.assertTrue(
-            type(long_name) == str,
+            isinstance(long_name, str),
             "GetLongPathNameW returned type '%s'" % (type(long_name),),
         )
         self.assertTrue(
diff --git a/win32/test/test_win32wnet.py b/win32/test/test_win32wnet.py
index 7a7301991c..11769fc926 100644
--- a/win32/test/test_win32wnet.py
+++ b/win32/test/test_win32wnet.py
@@ -59,14 +59,14 @@ def _checkItemAttributes(self, item, attrs):
             val = getattr(item, attr)
             if typ is int:
                 self.assertTrue(
-                    type(val) in (int,), "Attr %r has value %r" % (attr, val)
+                    isinstance(val, int), "Attr %r has value %r" % (attr, val)
                 )
                 new_val = val + 1
             elif typ is str:
                 if val is not None:
                     # on py2k, must be string or unicode.  py3k must be string or bytes.
                     self.assertTrue(
-                        type(val) in (str, str), "Attr %r has value %r" % (attr, val)
+                        isinstance(val, str), "Attr %r has value %r" % (attr, val)
                     )
                     new_val = val + " new value"
                 else: