diff --git a/pandas/tests/io/parser/test_unsupported.py b/pandas/tests/io/parser/test_unsupported.py
index 67f155817582c..bc8cb18ab0eaf 100644
--- a/pandas/tests/io/parser/test_unsupported.py
+++ b/pandas/tests/io/parser/test_unsupported.py
@@ -12,7 +12,10 @@
 
 import pytest
 
-from pandas.compat import is_platform_windows
+from pandas.compat import (
+    is_platform_mac,
+    is_platform_windows,
+)
 from pandas.errors import ParserError
 
 import pandas._testing as tm
@@ -174,9 +177,9 @@ def test_close_file_handle_on_invalid_usecols(all_parsers):
     if parser.engine == "pyarrow":
         pyarrow = pytest.importorskip("pyarrow")
         error = pyarrow.lib.ArrowKeyError
-        if is_platform_windows():
-            # GH#45547 causes timeouts on windows builds
-            pytest.skip("GH#45547 causing timeouts on windows builds 2022-01-22")
+        if is_platform_windows() or is_platform_mac():
+            # GH#45547 causes timeouts on windows/mac builds
+            pytest.skip("GH#45547 causing timeouts on windows/mac builds 2022-01-22")
 
     with tm.ensure_clean("test.csv") as fname:
         Path(fname).write_text("col1,col2\na,b\n1,2")