diff --git a/doc/source/whatsnew/v2.0.0.rst b/doc/source/whatsnew/v2.0.0.rst
index 9fd9faf057a8a..ad4dc9edffefd 100644
--- a/doc/source/whatsnew/v2.0.0.rst
+++ b/doc/source/whatsnew/v2.0.0.rst
@@ -247,6 +247,9 @@ Copy-on-Write improvements
   can never update the original Series or DataFrame. Therefore, an informative
   error is raised to the user instead of silently doing nothing (:issue:`49467`)
 
+- :meth:`DataFrame.replace` will now respect the Copy-on-Write mechanism
+  when ``inplace=True``.
+
 Copy-on-Write can be enabled through one of
 
 .. code-block:: python
diff --git a/pandas/core/internals/blocks.py b/pandas/core/internals/blocks.py
index e66011acb978b..ce48e6b85c430 100644
--- a/pandas/core/internals/blocks.py
+++ b/pandas/core/internals/blocks.py
@@ -665,6 +665,7 @@ def replace_list(
         dest_list: Sequence[Any],
         inplace: bool = False,
         regex: bool = False,
+        using_cow: bool = False,
     ) -> list[Block]:
         """
         See BlockManager.replace_list docstring.
@@ -674,7 +675,11 @@ def replace_list(
         if isinstance(values, Categorical):
             # TODO: avoid special-casing
             # GH49404
-            blk = self if inplace else self.copy()
+            if using_cow and inplace:
+                # TODO(CoW): Optimize
+                blk = self.copy()
+            else:
+                blk = self if inplace else self.copy()
             values = cast(Categorical, blk.values)
             values._replace(to_replace=src_list, value=dest_list, inplace=True)
             return [blk]
@@ -703,7 +708,11 @@ def replace_list(
 
         masks = [extract_bool_array(x) for x in masks]
 
-        rb = [self if inplace else self.copy()]
+        if using_cow and inplace:
+            # TODO(CoW): Optimize
+            rb = [self.copy()]
+        else:
+            rb = [self if inplace else self.copy()]
         for i, (src, dest) in enumerate(pairs):
             convert = i == src_len  # only convert once at the end
             new_rb: list[Block] = []
diff --git a/pandas/core/internals/managers.py b/pandas/core/internals/managers.py
index 517e6d7e48275..4973c0827245f 100644
--- a/pandas/core/internals/managers.py
+++ b/pandas/core/internals/managers.py
@@ -473,6 +473,7 @@ def replace_list(
             dest_list=dest_list,
             inplace=inplace,
             regex=regex,
+            using_cow=using_copy_on_write(),
         )
         bm._consolidate_inplace()
         return bm
diff --git a/pandas/tests/copy_view/test_replace.py b/pandas/tests/copy_view/test_replace.py
new file mode 100644
index 0000000000000..a1347d8e12950
--- /dev/null
+++ b/pandas/tests/copy_view/test_replace.py
@@ -0,0 +1,38 @@
+import numpy as np
+
+from pandas import (
+    Categorical,
+    DataFrame,
+)
+import pandas._testing as tm
+from pandas.tests.copy_view.util import get_array
+
+
+def test_replace_categorical_inplace_reference(using_copy_on_write):
+    df = DataFrame({"a": Categorical([1, 2, 3])})
+    df_orig = df.copy()
+    arr_a = get_array(df, "a")
+    view = df[:]  # noqa
+    df.replace(to_replace=[1], value=2, inplace=True)
+
+    if using_copy_on_write:
+        assert not np.shares_memory(get_array(df, "a").codes, arr_a.codes)
+        assert df._mgr._has_no_reference(0)
+        assert view._mgr._has_no_reference(0)
+        tm.assert_frame_equal(view, df_orig)
+    else:
+        assert np.shares_memory(get_array(df, "a").codes, arr_a.codes)
+
+
+def test_replace_inplace_reference(using_copy_on_write):
+    df = DataFrame({"a": [1.5, 2, 3]})
+    arr_a = get_array(df, "a")
+    view = df[:]  # noqa
+    df.replace(to_replace=[1.5], value=15.5, inplace=True)
+
+    if using_copy_on_write:
+        assert not np.shares_memory(get_array(df, "a"), arr_a)
+        assert df._mgr._has_no_reference(0)
+        assert view._mgr._has_no_reference(0)
+    else:
+        assert np.shares_memory(get_array(df, "a"), arr_a)