diff --git a/Lib/uuid.py b/Lib/uuid.py
index 66383218e70c0d..dcf5e90fce340b 100644
--- a/Lib/uuid.py
+++ b/Lib/uuid.py
@@ -533,6 +533,7 @@ def _netbios_getnode():
 
 _generate_time_safe = _UuidCreate = None
 _has_uuid_generate_time_safe = None
+_little_endian = None
 
 # Import optional C extension at toplevel, to help disabling it when testing
 try:
@@ -545,7 +546,7 @@ def _load_system_functions():
     """
     Try to load platform-specific functions for generating uuids.
     """
-    global _generate_time_safe, _UuidCreate, _has_uuid_generate_time_safe
+    global _generate_time_safe, _UuidCreate, _has_uuid_generate_time_safe, _little_endian
 
     if _has_uuid_generate_time_safe is not None:
         return
@@ -564,6 +565,7 @@ def _load_system_functions():
     elif _uuid is not None:
         _generate_time_safe = _uuid.generate_time_safe
         _has_uuid_generate_time_safe = _uuid.has_uuid_generate_time_safe
+        _little_endian = _uuid.little_endian
         return
 
     try:
@@ -592,6 +594,7 @@ def _generate_time_safe():
                     res = _uuid_generate_time_safe(_buffer)
                     return bytes(_buffer.raw), res
                 _has_uuid_generate_time_safe = True
+                _little_endian = False
                 break
 
             elif hasattr(lib, 'uuid_generate_time'):    # pragma: nocover
@@ -602,6 +605,7 @@ def _generate_time_safe():
                     _buffer = ctypes.create_string_buffer(16)
                     _uuid_generate_time(_buffer)
                     return bytes(_buffer.raw), None
+                _little_endian = False
                 break
 
         # On Windows prior to 2000, UuidCreate gives a UUID containing the
@@ -630,7 +634,10 @@ def _unix_getnode():
     or ctypes."""
     _load_system_functions()
     uuid_time, _ = _generate_time_safe()
-    return UUID(bytes=uuid_time).node
+    if _little_endian:
+        return UUID(bytes_le=uuid_time).node
+    else:
+        return UUID(bytes=uuid_time).node
 
 def _windll_getnode():
     """Get the hardware address on Windows using ctypes."""
@@ -707,7 +714,10 @@ def uuid1(node=None, clock_seq=None):
             is_safe = SafeUUID(safely_generated)
         except ValueError:
             is_safe = SafeUUID.unknown
-        return UUID(bytes=uuid_time, is_safe=is_safe)
+        if _little_endian:
+            return UUID(bytes_le=uuid_time, is_safe=is_safe)
+        else:
+            return UUID(bytes=uuid_time, is_safe=is_safe)
 
     global _last_timestamp
     import time
diff --git a/Misc/NEWS.d/next/Library/2018-05-24-17-41-36.bpo-32493.5tAoAu.rst b/Misc/NEWS.d/next/Library/2018-05-24-17-41-36.bpo-32493.5tAoAu.rst
new file mode 100644
index 00000000000000..32f88dd0388d5a
--- /dev/null
+++ b/Misc/NEWS.d/next/Library/2018-05-24-17-41-36.bpo-32493.5tAoAu.rst
@@ -0,0 +1 @@
+Fixed :func:`uuid.uuid1` on FreeBSD.
diff --git a/Modules/_uuidmodule.c b/Modules/_uuidmodule.c
index 3a0c0573826692..9cd033d20f873c 100644
--- a/Modules/_uuidmodule.c
+++ b/Modules/_uuidmodule.c
@@ -19,7 +19,7 @@ py_uuid_generate_time_safe(PyObject *Py_UNUSED(context),
 
     res = uuid_generate_time_safe(uuid);
     return Py_BuildValue("y#i", (const char *) uuid, sizeof(uuid), res);
-#elif HAVE_UUID_CREATE
+#elif defined(HAVE_UUID_CREATE)
     uint32_t status;
     uuid_create(&uuid, &status);
     return Py_BuildValue("y#i", (const char *) &uuid, sizeof(uuid), (int) status);
@@ -51,6 +51,12 @@ PyInit__uuid(void)
     int has_uuid_generate_time_safe = 1;
 #else
     int has_uuid_generate_time_safe = 0;
+#endif
+    /* uuid_create() creates bytes with platform-depending endianess */
+#if !defined(HAVE_UUID_GENERATE_TIME_SAFE) && defined(HAVE_UUID_CREATE)
+    int little_endian = PY_LITTLE_ENDIAN;
+#else
+    int little_endian = 0;
 #endif
     mod = PyModule_Create(&uuidmodule);
     if (mod == NULL) {
@@ -58,6 +64,11 @@ PyInit__uuid(void)
     }
     if (PyModule_AddIntConstant(mod, "has_uuid_generate_time_safe",
                                 has_uuid_generate_time_safe) < 0) {
+        Py_DECREF(mod);
+        return NULL;
+    }
+    if (PyModule_AddIntConstant(mod, "little_endian", little_endian) < 0) {
+        Py_DECREF(mod);
         return NULL;
     }