diff --git a/packages/toolkit/src/query/createApi.ts b/packages/toolkit/src/query/createApi.ts
index c63c5a2b82..2b2daec350 100644
--- a/packages/toolkit/src/query/createApi.ts
+++ b/packages/toolkit/src/query/createApi.ts
@@ -1,13 +1,15 @@
 import type { Api, ApiContext, Module, ModuleName } from './apiTypes'
 import type { CombinedState } from './core/apiState'
 import type { BaseQueryArg, BaseQueryFn } from './baseQueryTypes'
-import type { SerializeQueryArgs } from './defaultSerializeQueryArgs'
-import { defaultSerializeQueryArgs } from './defaultSerializeQueryArgs'
+import {
+  defaultSerializeQueryArgs,
+  SerializeQueryArgs,
+} from './defaultSerializeQueryArgs'
 import type {
   EndpointBuilder,
   EndpointDefinitions,
 } from './endpointDefinitions'
-import { DefinitionType } from './endpointDefinitions'
+import { DefinitionType, isQueryDefinition } from './endpointDefinitions'
 import { nanoid } from '@reduxjs/toolkit'
 import type { AnyAction } from '@reduxjs/toolkit'
 import type { NoInfer } from './tsHelpers'
@@ -236,15 +238,25 @@ export function buildCreateApi<Modules extends [Module<any>, ...Module<any>[]]>(
       })
     )
 
-    const optionsWithDefaults = {
+    const optionsWithDefaults: CreateApiOptions<any, any, any, any> = {
       reducerPath: 'api',
-      serializeQueryArgs: defaultSerializeQueryArgs,
       keepUnusedDataFor: 60,
       refetchOnMountOrArgChange: false,
       refetchOnFocus: false,
       refetchOnReconnect: false,
       ...options,
       extractRehydrationInfo,
+      serializeQueryArgs(queryArgsApi) {
+        let finalSerializeQueryArgs = defaultSerializeQueryArgs
+        if ('serializeQueryArgs' in queryArgsApi.endpointDefinition) {
+          finalSerializeQueryArgs =
+            queryArgsApi.endpointDefinition.serializeQueryArgs!
+        } else if (options.serializeQueryArgs) {
+          finalSerializeQueryArgs = options.serializeQueryArgs
+        }
+
+        return finalSerializeQueryArgs(queryArgsApi)
+      },
       tagTypes: [...(options.tagTypes || [])],
     }
 
@@ -266,8 +278,8 @@ export function buildCreateApi<Modules extends [Module<any>, ...Module<any>[]]>(
       enhanceEndpoints({ addTagTypes, endpoints }) {
         if (addTagTypes) {
           for (const eT of addTagTypes) {
-            if (!optionsWithDefaults.tagTypes.includes(eT as any)) {
-              optionsWithDefaults.tagTypes.push(eT as any)
+            if (!optionsWithDefaults.tagTypes!.includes(eT as any)) {
+              ;(optionsWithDefaults.tagTypes as any[]).push(eT)
             }
           }
         }
@@ -290,7 +302,7 @@ export function buildCreateApi<Modules extends [Module<any>, ...Module<any>[]]>(
     } as Api<BaseQueryFn, {}, string, string, Modules[number]['name']>
 
     const initializedModules = modules.map((m) =>
-      m.init(api as any, optionsWithDefaults, context)
+      m.init(api as any, optionsWithDefaults as any, context)
     )
 
     function injectEndpoints(
@@ -319,6 +331,7 @@ export function buildCreateApi<Modules extends [Module<any>, ...Module<any>[]]>(
 
           continue
         }
+
         context.endpointDefinitions[endpointName] = definition
         for (const m of initializedModules) {
           m.injectEndpoint(endpointName, definition)
diff --git a/packages/toolkit/src/query/endpointDefinitions.ts b/packages/toolkit/src/query/endpointDefinitions.ts
index 44ce1a41b1..02293cc41c 100644
--- a/packages/toolkit/src/query/endpointDefinitions.ts
+++ b/packages/toolkit/src/query/endpointDefinitions.ts
@@ -1,4 +1,5 @@
 import type { AnyAction, ThunkDispatch } from '@reduxjs/toolkit'
+import { SerializeQueryArgs } from './defaultSerializeQueryArgs'
 import type { RootState } from './core/apiState'
 import type {
   BaseQueryExtraOptions,
@@ -272,6 +273,8 @@ export interface QueryExtraOptions<
    * Not to be used. A query should not invalidate tags in the cache.
    */
   invalidatesTags?: never
+
+  serializeQueryArgs?: SerializeQueryArgs<any>
 }
 
 export type QueryDefinition<
diff --git a/packages/toolkit/src/query/tests/createApi.test.ts b/packages/toolkit/src/query/tests/createApi.test.ts
index fbf729841a..0fbfcb9a75 100644
--- a/packages/toolkit/src/query/tests/createApi.test.ts
+++ b/packages/toolkit/src/query/tests/createApi.test.ts
@@ -17,6 +17,7 @@ import {
 } from './helpers'
 import { server } from './mocks/server'
 import { rest } from 'msw'
+import { SerializeQueryArgs } from '../defaultSerializeQueryArgs'
 
 const originalEnv = process.env.NODE_ENV
 beforeAll(() => void ((process.env as any).NODE_ENV = 'development'))
@@ -818,3 +819,79 @@ describe('structuralSharing flag behaviors', () => {
     expect(firstRef.data === secondRef.data).toBeFalsy()
   })
 })
+
+describe('custom serializeQueryArgs per endpoint', () => {
+  const customArgsSerializer: SerializeQueryArgs<number> = ({
+    endpointName,
+    queryArgs,
+  }) => `${endpointName}-${queryArgs}`
+
+  type SuccessResponse = { value: 'success' }
+
+  const serializer1 = jest.fn(customArgsSerializer)
+
+  const api = createApi({
+    baseQuery: fetchBaseQuery({ baseUrl: 'https://example.com' }),
+    serializeQueryArgs: ({ endpointName, queryArgs }) =>
+      `base-${endpointName}-${queryArgs}`,
+    endpoints: (build) => ({
+      queryWithNoSerializer: build.query<SuccessResponse, number>({
+        query: (arg) => `${arg}`,
+      }),
+      queryWithCustomSerializer: build.query<SuccessResponse, number>({
+        query: (arg) => `${arg}`,
+        serializeQueryArgs: serializer1,
+      }),
+    }),
+  })
+
+  const storeRef = setupApiStore(api)
+
+  it('Works via createApi', async () => {
+    await storeRef.store.dispatch(
+      api.endpoints.queryWithNoSerializer.initiate(99)
+    )
+
+    expect(serializer1).toHaveBeenCalledTimes(0)
+
+    await storeRef.store.dispatch(
+      api.endpoints.queryWithCustomSerializer.initiate(42)
+    )
+
+    expect(serializer1).toHaveBeenCalled()
+
+    expect(
+      storeRef.store.getState().api.queries['base-queryWithNoSerializer-99']
+    ).toBeTruthy()
+
+    expect(
+      storeRef.store.getState().api.queries['queryWithCustomSerializer-42']
+    ).toBeTruthy()
+  })
+
+  const serializer2 = jest.fn(customArgsSerializer)
+
+  const injectedApi = api.injectEndpoints({
+    endpoints: (build) => ({
+      injectedQueryWithCustomSerializer: build.query<SuccessResponse, number>({
+        query: (arg) => `${arg}`,
+        serializeQueryArgs: serializer2,
+      }),
+    }),
+  })
+
+  it('Works via injectEndpoints', async () => {
+    expect(serializer2).toHaveBeenCalledTimes(0)
+
+    await storeRef.store.dispatch(
+      injectedApi.endpoints.injectedQueryWithCustomSerializer.initiate(5)
+    )
+
+    expect(serializer2).toHaveBeenCalled()
+    expect(
+      storeRef.store.getState().api.queries[
+        'injectedQueryWithCustomSerializer-5'
+      ]
+    ).toBeTruthy()
+  })
+})