diff --git a/openssl-sys/build/expando.c b/openssl-sys/build/expando.c
index cebed1b70..038051639 100644
--- a/openssl-sys/build/expando.c
+++ b/openssl-sys/build/expando.c
@@ -111,6 +111,10 @@ RUST_CONF_OPENSSL_NO_SHA
 RUST_CONF_OPENSSL_NO_SRP
 #endif
 
+#ifdef OPENSSL_NO_SRTP
+RUST_CONF_OPENSSL_NO_SRTP
+#endif
+
 #ifdef OPENSSL_NO_SSL3_METHOD
 RUST_CONF_OPENSSL_NO_SSL3_METHOD
 #endif
diff --git a/openssl-sys/build/main.rs b/openssl-sys/build/main.rs
index 4007a2658..619214aee 100644
--- a/openssl-sys/build/main.rs
+++ b/openssl-sys/build/main.rs
@@ -120,7 +120,7 @@ fn check_ssl_kind() {
 }
 
 fn main() {
-    println!("cargo:rustc-check-cfg=cfg(osslconf, values(\"OPENSSL_NO_OCB\", \"OPENSSL_NO_SM4\", \"OPENSSL_NO_SEED\", \"OPENSSL_NO_CHACHA\", \"OPENSSL_NO_CAST\", \"OPENSSL_NO_IDEA\", \"OPENSSL_NO_CAMELLIA\", \"OPENSSL_NO_RC4\", \"OPENSSL_NO_BF\", \"OPENSSL_NO_PSK\", \"OPENSSL_NO_DEPRECATED_3_0\", \"OPENSSL_NO_SCRYPT\", \"OPENSSL_NO_SM3\", \"OPENSSL_NO_RMD160\", \"OPENSSL_NO_EC2M\", \"OPENSSL_NO_OCSP\", \"OPENSSL_NO_CMS\", \"OPENSSL_NO_COMP\", \"OPENSSL_NO_SOCK\", \"OPENSSL_NO_STDIO\", \"OPENSSL_NO_EC\", \"OPENSSL_NO_SSL3_METHOD\", \"OPENSSL_NO_KRB5\", \"OPENSSL_NO_TLSEXT\", \"OPENSSL_NO_SRP\", \"OPENSSL_NO_RFC3779\", \"OPENSSL_NO_SHA\", \"OPENSSL_NO_NEXTPROTONEG\", \"OPENSSL_NO_ENGINE\", \"OPENSSL_NO_BUF_FREELISTS\", \"OPENSSL_NO_RC2\"))");
+    println!("cargo:rustc-check-cfg=cfg(osslconf, values(\"OPENSSL_NO_OCB\", \"OPENSSL_NO_SM4\", \"OPENSSL_NO_SEED\", \"OPENSSL_NO_CHACHA\", \"OPENSSL_NO_CAST\", \"OPENSSL_NO_IDEA\", \"OPENSSL_NO_CAMELLIA\", \"OPENSSL_NO_RC4\", \"OPENSSL_NO_BF\", \"OPENSSL_NO_PSK\", \"OPENSSL_NO_DEPRECATED_3_0\", \"OPENSSL_NO_SCRYPT\", \"OPENSSL_NO_SM3\", \"OPENSSL_NO_RMD160\", \"OPENSSL_NO_EC2M\", \"OPENSSL_NO_OCSP\", \"OPENSSL_NO_CMS\", \"OPENSSL_NO_COMP\", \"OPENSSL_NO_SOCK\", \"OPENSSL_NO_STDIO\", \"OPENSSL_NO_EC\", \"OPENSSL_NO_SSL3_METHOD\", \"OPENSSL_NO_KRB5\", \"OPENSSL_NO_TLSEXT\", \"OPENSSL_NO_SRP\", \"OPENSSL_NO_SRTP\", \"OPENSSL_NO_RFC3779\", \"OPENSSL_NO_SHA\", \"OPENSSL_NO_NEXTPROTONEG\", \"OPENSSL_NO_ENGINE\", \"OPENSSL_NO_BUF_FREELISTS\", \"OPENSSL_NO_RC2\"))");
 
     println!("cargo:rustc-check-cfg=cfg(openssl)");
     println!("cargo:rustc-check-cfg=cfg(libressl)");
diff --git a/openssl-sys/build/run_bindgen.rs b/openssl-sys/build/run_bindgen.rs
index cc0efd8b5..946f42f53 100644
--- a/openssl-sys/build/run_bindgen.rs
+++ b/openssl-sys/build/run_bindgen.rs
@@ -45,7 +45,7 @@ const INCLUDES: &str = "
 #include <openssl/cms.h>
 #endif
 
-#if !(defined(OPENSSL_IS_BORINGSSL) || defined(OPENSSL_IS_AWSLC))
+#if !defined(OPENSSL_NO_COMP) && !(defined(OPENSSL_IS_BORINGSSL) || defined(OPENSSL_IS_AWSLC))
 #include <openssl/comp.h>
 #endif
 
diff --git a/openssl-sys/src/handwritten/types.rs b/openssl-sys/src/handwritten/types.rs
index d465a4414..a4b90d789 100644
--- a/openssl-sys/src/handwritten/types.rs
+++ b/openssl-sys/src/handwritten/types.rs
@@ -1072,9 +1072,9 @@ cfg_if! {
 pub enum COMP_CTX {}
 
 cfg_if! {
-    if #[cfg(any(ossl110, libressl350))] {
+    if #[cfg(all(any(ossl110, libressl350), not(osslconf = "OPENSSL_NO_COMP")))] {
         pub enum COMP_METHOD {}
-    } else {
+    } else if #[cfg(not(osslconf = "OPENSSL_NO_COMP"))] {
         #[repr(C)]
         pub struct COMP_METHOD {
             pub type_: c_int,
diff --git a/openssl-sys/src/tls1.rs b/openssl-sys/src/tls1.rs
index 7ff0b9df9..99e545087 100644
--- a/openssl-sys/src/tls1.rs
+++ b/openssl-sys/src/tls1.rs
@@ -109,6 +109,7 @@ pub unsafe fn SSL_CTX_set_tlsext_status_cb(
     )
 }
 
+#[cfg(not(osslconf = "OPENSSL_NO_SRTP"))]
 pub unsafe fn SSL_CTX_set_tlsext_status_arg(ctx: *mut SSL_CTX, arg: *mut c_void) -> c_long {
     SSL_CTX_ctrl(ctx, SSL_CTRL_SET_TLSEXT_STATUS_REQ_CB_ARG, 0, arg)
 }
diff --git a/openssl/build.rs b/openssl/build.rs
index d6d65798f..704a0b58d 100644
--- a/openssl/build.rs
+++ b/openssl/build.rs
@@ -7,7 +7,7 @@
 use std::env;
 
 fn main() {
-    println!("cargo:rustc-check-cfg=cfg(osslconf, values(\"OPENSSL_NO_OCB\", \"OPENSSL_NO_SM4\", \"OPENSSL_NO_SEED\", \"OPENSSL_NO_CHACHA\", \"OPENSSL_NO_CAST\", \"OPENSSL_NO_IDEA\", \"OPENSSL_NO_CAMELLIA\", \"OPENSSL_NO_RC4\", \"OPENSSL_NO_BF\", \"OPENSSL_NO_PSK\", \"OPENSSL_NO_DEPRECATED_3_0\", \"OPENSSL_NO_SCRYPT\", \"OPENSSL_NO_SM3\", \"OPENSSL_NO_RMD160\", \"OPENSSL_NO_EC2M\", \"OPENSSL_NO_OCSP\", \"OPENSSL_NO_CMS\", \"OPENSSL_NO_EC\", \"OPENSSL_NO_ARGON2\", \"OPENSSL_NO_RC2\"))");
+    println!("cargo:rustc-check-cfg=cfg(osslconf, values(\"OPENSSL_NO_OCB\", \"OPENSSL_NO_SM4\", \"OPENSSL_NO_SEED\", \"OPENSSL_NO_CHACHA\", \"OPENSSL_NO_CAST\", \"OPENSSL_NO_IDEA\", \"OPENSSL_NO_CAMELLIA\", \"OPENSSL_NO_RC4\", \"OPENSSL_NO_BF\", \"OPENSSL_NO_PSK\", \"OPENSSL_NO_DEPRECATED_3_0\", \"OPENSSL_NO_SCRYPT\", \"OPENSSL_NO_SM3\", \"OPENSSL_NO_RMD160\", \"OPENSSL_NO_EC2M\", \"OPENSSL_NO_OCSP\", \"OPENSSL_NO_SRTP\", \"OPENSSL_NO_CMS\", \"OPENSSL_NO_EC\", \"OPENSSL_NO_ARGON2\", \"OPENSSL_NO_RC2\"))");
 
     println!("cargo:rustc-check-cfg=cfg(libressl)");
     println!("cargo:rustc-check-cfg=cfg(boringssl)");
diff --git a/openssl/src/ssl/mod.rs b/openssl/src/ssl/mod.rs
index 696be0134..7b6ece655 100644
--- a/openssl/src/ssl/mod.rs
+++ b/openssl/src/ssl/mod.rs
@@ -72,6 +72,7 @@ use crate::nid::Nid;
 use crate::pkey::{HasPrivate, PKeyRef, Params, Private};
 #[cfg(ossl300)]
 use crate::pkey::{PKey, Public};
+#[cfg(not(osslconf = "OPENSSL_NO_SRTP"))]
 use crate::srtp::{SrtpProtectionProfile, SrtpProtectionProfileRef};
 use crate::ssl::bio::BioMethod;
 use crate::ssl::callbacks::*;
@@ -1269,6 +1270,7 @@ impl SslContextBuilder {
     }
 
     /// Enables the DTLS extension "use_srtp" as defined in RFC5764.
+    #[cfg(not(osslconf = "OPENSSL_NO_SRTP"))]
     #[corresponds(SSL_CTX_set_tlsext_use_srtp)]
     pub fn set_tlsext_use_srtp(&mut self, protocols: &str) -> Result<(), ErrorStack> {
         unsafe {
@@ -2675,6 +2677,7 @@ impl SslRef {
     }
 
     /// Enables the DTLS extension "use_srtp" as defined in RFC5764.
+    #[cfg(not(osslconf = "OPENSSL_NO_SRTP"))]
     #[corresponds(SSL_set_tlsext_use_srtp)]
     pub fn set_tlsext_use_srtp(&mut self, protocols: &str) -> Result<(), ErrorStack> {
         unsafe {
@@ -2693,6 +2696,7 @@ impl SslRef {
     /// Gets all SRTP profiles that are enabled for handshake via set_tlsext_use_srtp
     ///
     /// DTLS extension "use_srtp" as defined in RFC5764 has to be enabled.
+    #[cfg(not(osslconf = "OPENSSL_NO_SRTP"))]
     #[corresponds(SSL_get_srtp_profiles)]
     pub fn srtp_profiles(&self) -> Option<&StackRef<SrtpProtectionProfile>> {
         unsafe {
@@ -2705,6 +2709,7 @@ impl SslRef {
     /// Gets the SRTP profile selected by handshake.
     ///
     /// DTLS extension "use_srtp" as defined in RFC5764 has to be enabled.
+    #[cfg(not(osslconf = "OPENSSL_NO_SRTP"))]
     #[corresponds(SSL_get_selected_srtp_profile)]
     pub fn selected_srtp_profile(&self) -> Option<&SrtpProtectionProfileRef> {
         unsafe {