diff --git a/python/sglang/srt/entrypoints/engine.py b/python/sglang/srt/entrypoints/engine.py
index 33aab232fe..bf7371fff6 100644
--- a/python/sglang/srt/entrypoints/engine.py
+++ b/python/sglang/srt/entrypoints/engine.py
@@ -278,6 +278,10 @@ def __exit__(self, exc_type, exc_value, traceback):
         self.shutdown()
         return False
 
+    def flush_cache(self):
+        loop = asyncio.get_event_loop()
+        return loop.run_until_complete(self.tokenizer_manager.flush_cache())
+
     def start_profile(self):
         loop = asyncio.get_event_loop()
         loop.run_until_complete(self.tokenizer_manager.start_profile())
diff --git a/python/sglang/srt/entrypoints/http_server.py b/python/sglang/srt/entrypoints/http_server.py
index 1f93b475c2..2e5944a70b 100644
--- a/python/sglang/srt/entrypoints/http_server.py
+++ b/python/sglang/srt/entrypoints/http_server.py
@@ -310,11 +310,11 @@ async def classify_request(obj: EmbeddingReqInput, request: Request):
 @app.api_route("/flush_cache", methods=["GET", "POST"])
 async def flush_cache():
     """Flush the radix cache."""
-    _global_state.tokenizer_manager.flush_cache()
+    ret = await _global_state.tokenizer_manager.flush_cache()
     return Response(
         content="Cache flushed.\nPlease check backend logs for more details. "
         "(When there are running or waiting requests, the operation will not be performed.)\n",
-        status_code=200,
+        status_code=200 if ret.success else HTTPStatus.BAD_REQUEST,
     )
 
 
diff --git a/python/sglang/srt/managers/io_struct.py b/python/sglang/srt/managers/io_struct.py
index 00affa0a4e..d2d5c591a2 100644
--- a/python/sglang/srt/managers/io_struct.py
+++ b/python/sglang/srt/managers/io_struct.py
@@ -665,10 +665,15 @@ class BatchEmbeddingOut:
 
 
 @dataclass
-class FlushCacheReq:
+class FlushCacheReqInput:
     pass
 
 
+@dataclass
+class FlushCacheReqOutput:
+    success: bool
+
+
 @dataclass
 class UpdateWeightFromDiskReqInput:
     # The model path with the new weights
diff --git a/python/sglang/srt/managers/scheduler.py b/python/sglang/srt/managers/scheduler.py
index 383cd68094..24f5d4aa1a 100644
--- a/python/sglang/srt/managers/scheduler.py
+++ b/python/sglang/srt/managers/scheduler.py
@@ -59,7 +59,8 @@
     CloseSessionReqInput,
     ExpertDistributionReq,
     ExpertDistributionReqOutput,
-    FlushCacheReq,
+    FlushCacheReqInput,
+    FlushCacheReqOutput,
     GetInternalStateReq,
     GetInternalStateReqOutput,
     GetWeightsByNameReqInput,
@@ -400,7 +401,7 @@ def __init__(
             [
                 (TokenizedGenerateReqInput, self.handle_generate_request),
                 (TokenizedEmbeddingReqInput, self.handle_embedding_request),
-                (FlushCacheReq, self.flush_cache_wrapped),
+                (FlushCacheReqInput, self.flush_cache_wrapped),
                 (AbortReq, self.abort_request),
                 (OpenSessionReqInput, self.open_session),
                 (CloseSessionReqInput, self.close_session),
@@ -1652,8 +1653,9 @@ def watchdog_thread(self):
         time.sleep(5)
         self.parent_process.send_signal(signal.SIGQUIT)
 
-    def flush_cache_wrapped(self, recv_req: FlushCacheReq):
-        self.flush_cache()
+    def flush_cache_wrapped(self, recv_req: FlushCacheReqInput):
+        success = self.flush_cache()
+        return FlushCacheReqOutput(success=success)
 
     def flush_cache(self):
         """Flush the memory pool and cache."""
diff --git a/python/sglang/srt/managers/tokenizer_manager.py b/python/sglang/srt/managers/tokenizer_manager.py
index 33afffbd6d..93e74ad27f 100644
--- a/python/sglang/srt/managers/tokenizer_manager.py
+++ b/python/sglang/srt/managers/tokenizer_manager.py
@@ -62,7 +62,8 @@
     EmbeddingReqInput,
     ExpertDistributionReq,
     ExpertDistributionReqOutput,
-    FlushCacheReq,
+    FlushCacheReqInput,
+    FlushCacheReqOutput,
     GenerateReqInput,
     GetInternalStateReq,
     GetInternalStateReqOutput,
@@ -258,6 +259,9 @@ def __init__(
         self.resume_memory_occupation_communicator = _Communicator(
             self.send_to_scheduler, server_args.dp_size
         )
+        self.flush_cache_communicator = _Communicator(
+            self.send_to_scheduler, server_args.dp_size
+        )
         self.start_profile_communicator = _Communicator(
             self.send_to_scheduler, server_args.dp_size
         )
@@ -308,6 +312,10 @@ def __init__(
                     ResumeMemoryOccupationReqOutput,
                     self.resume_memory_occupation_communicator.handle_recv,
                 ),
+                (
+                    FlushCacheReqOutput,
+                    self.flush_cache_communicator.handle_recv,
+                ),
                 (
                     ProfileReqOutput,
                     self.start_profile_communicator.handle_recv,
@@ -616,9 +624,8 @@ async def _handle_batch_request(
                     except StopAsyncIteration:
                         pass
 
-    def flush_cache(self):
-        req = FlushCacheReq()
-        self.send_to_scheduler.send_pyobj(req)
+    async def flush_cache(self) -> FlushCacheReqOutput:
+        return await self.flush_cache_communicator(FlushCacheReqInput())
 
     def abort_request(self, rid: str):
         if rid not in self.rid_to_state: