diff --git a/connexion/decorators/response.py b/connexion/decorators/response.py
index 160ace61c..0aa58870d 100644
--- a/connexion/decorators/response.py
+++ b/connexion/decorators/response.py
@@ -138,7 +138,8 @@ def _unpack_handler_response(
         elif len(handler_response) == 2:
             data, status_code_or_headers = handler_response
             if isinstance(status_code_or_headers, int):
-                status_code = status_code_or_headers
+                # Extra int call because of int subclasses such as http.HTTPStatus (IntEnum)
+                status_code = int(status_code_or_headers)
             elif isinstance(status_code_or_headers, Enum) and isinstance(
                 status_code_or_headers.value, int
             ):
diff --git a/tests/api/test_responses.py b/tests/api/test_responses.py
index e9649bf0c..afcb39c49 100644
--- a/tests/api/test_responses.py
+++ b/tests/api/test_responses.py
@@ -140,6 +140,13 @@ def test_pass_through(simple_app):
     )
 
 
+def test_can_use_httpstatus_enum(simple_openapi_app):
+    app_client = simple_openapi_app.test_client()
+
+    response = app_client.get("/v1.0/httpstatus")
+    assert response.status_code == 201
+
+
 def test_empty(simple_app):
     app_client = simple_app.test_client()
 
diff --git a/tests/fakeapi/hello/__init__.py b/tests/fakeapi/hello/__init__.py
index de2af8fdd..b6d6c00ac 100644
--- a/tests/fakeapi/hello/__init__.py
+++ b/tests/fakeapi/hello/__init__.py
@@ -1,6 +1,7 @@
 import asyncio
 import datetime
 import uuid
+from http import HTTPStatus
 
 import flask
 from connexion import NoContent, ProblemException, context, request
@@ -737,3 +738,7 @@ def get_streaming_response():
 
 async def async_route():
     return {}, 200
+
+
+def httpstatus():
+    return {}, HTTPStatus.CREATED
diff --git a/tests/fixtures/simple/openapi.yaml b/tests/fixtures/simple/openapi.yaml
index c4ce61773..e183a1cb9 100644
--- a/tests/fixtures/simple/openapi.yaml
+++ b/tests/fixtures/simple/openapi.yaml
@@ -1316,7 +1316,23 @@ paths:
       responses:
         200:
           description: 'OK'
-
+  /httpstatus:
+    get:
+      operationId: fakeapi.hello.httpstatus
+      responses:
+        201:
+          description: "happy path"
+        default:
+          description: "default"
+          content:
+            application/json:
+              schema:
+                type: object
+                properties:
+                  error_code:
+                    type: integer
+                required:
+                  - error_code
 
 servers:
   - url: http://localhost:{port}/{basePath}