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Unless I'm mistaken, LD_RUN_PATH is only used by the GNU Linker (or maybe all ELF linkers, I'm not sure where to look for an authoritative answer). MacOS uses dyld, which I believe ignores this variable (again, I'm extrapolating based on naming conventions and the lack of internet references suggesting otherwise).
If that's the case, shouldn't MakeMaker avoid setting this variable? I realize it isn't hurting anything, but the noise is confusing when debugging.
Others have already gone in this direction:
mattn/p5-Devel-CheckLib@61c8295